MBX-4132
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555763

CAS#: 2286411-30-9

Description: MBX-4132 inhibit trans translation by binding to the bacterial ribosome.

Chemical Structure

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MBX-4132
CAS# 2286411-30-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 555763
Name: MBX-4132
CAS#: 2286411-30-9
Chemical Formula: C18H15FN4O2
Exact Mass: 338.12
Molecular Weight: 338.342
Elemental Analysis: C, 63.90; H, 4.47; F, 5.62; N, 16.56; O, 9.46

Price and Availability

Size Price Availability Quantity
50mg USD 850 2 Weeks
100mg USD 1350 2 Weeks
200mg USD 2050 2 Weeks
500mg USD 3850 2 Weeks
1g USD 5850 2 Weeks
2g USD 7950 2 Weeks
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Synonym: MBX-4132; MBX 4132; MBX4132;

IUPAC/Chemical Name: N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

InChi Key: OZHWSOOZCIJFQN-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H15FN4O2/c19-15-7-5-13(6-8-15)16-21-22-17(25-16)20-18(24)23-10-9-12-3-1-2-4-14(12)11-23/h1-8H,9-11H2,(H,20,22,24)

SMILES Code: O=C(NC1=NN=C(C2=CC=C(F)C=C2)O1)N3CCC4=CC=CC=C4C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: MBX-4132, a member of a chemical class called oxadiazoles that inhibit trans translation by binding to the bacterial ribosome.
In vitro activity: TBD
In vivo activity: Here, this study reports optimization of the pharmacokinetic and antibiotic properties of the acylaminooxadiazoles, producing MBX-4132, which clears multiple-drug resistant Neisseria gonorrhoeae infection in mice after a single oral dose. Reference: Nat Commun. 2021 Mar 19;12(1):1799. https://pubmed.ncbi.nlm.nih.gov/33741965/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.0 73.89

Preparing Stock Solutions

The following data is based on the product molecular weight 338.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: Aron ZD, Mehrani A, Hoffer ED, Connolly KL, Srinivas P, Torhan MC, Alumasa JN, Cabrera M, Hosangadi D, Barbor JS, Cardinale SC, Kwasny SM, Morin LR, Butler MM, Opperman TJ, Bowlin TL, Jerse A, Stagg SM, Dunham CM, Keiler KC. trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nat Commun. 2021 Mar 19;12(1):1799. doi: 10.1038/s41467-021-22012-7. PMID: 33741965; PMCID: PMC7979765.
In vitro protocol: TBD
In vivo protocol: Aron ZD, Mehrani A, Hoffer ED, Connolly KL, Srinivas P, Torhan MC, Alumasa JN, Cabrera M, Hosangadi D, Barbor JS, Cardinale SC, Kwasny SM, Morin LR, Butler MM, Opperman TJ, Bowlin TL, Jerse A, Stagg SM, Dunham CM, Keiler KC. trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nat Commun. 2021 Mar 19;12(1):1799. doi: 10.1038/s41467-021-22012-7. PMID: 33741965; PMCID: PMC7979765.

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