8-M-PDOT
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471039

CAS#: 134865-70-6

Description: 8-M-PDOT is a selective melatonin receptor agonist

Chemical Structure

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8-M-PDOT
CAS# 134865-70-6
Instruction

Theoretical Analysis

MedKoo Cat#: 471039
Name: 8-M-PDOT
CAS#: 134865-70-6
Chemical Formula: C14H19NO2
Exact Mass: 233.14
Molecular Weight: 233.310
Elemental Analysis: C, 72.07; H, 8.21; N, 6.00; O, 13.71

Price and Availability

Size Price Availability Quantity
10mg USD 280
25mg USD 510
50mg USD 860
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Synonym: AH 002, AH002, AH-002, 8-M-PDOT

IUPAC/Chemical Name: N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide

InChi Key: RVIGBTUDFAGRTQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19NO2/c1-3-14(16)15-11-8-7-10-5-4-6-13(17-2)12(10)9-11/h4-6,11H,3,7-9H2,1-2H3,(H,15,16)

SMILES Code: CCC(NC1CC2=C(C=CC=C2OC)CC1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 233.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Noseda, A.C., Targa, A.D., Rodrigues, L.S., et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 9(1), 47-54 (2016).

2. Browning, C., Beresford, I., Fraser, N., et al. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br. J. Pharmacol. 129(5), 877-886 (2000).

3. Dubocovich ML, Masana MI, Iacob S, Sauri DM., Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor., Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75.

4. Dubocovich ML, Melatonin receptors: are there multiple subtypes? Trends Pharmacol Sci. 1995 Feb;16(2):50-6.