TAMRA alkyne, 6-isomer

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MedKoo CAT#: 558821

CAS#: 1352649-44-5

Description: Tetramethylrhodamine (TAMRA) alkyne, pure 6-isomer. TAMRA is a popular dye that is used in qPCR and other applications. It forms a FRET pair with FAM (serving as an acceptor). This product is a terminal alkyne for copper-catalyzed Click chemistry. It can be conjugated with azide groups using CuAAc reaction.

Chemical Structure

TAMRA alkyne, 6-isomer
CAS# 1352649-44-5

Theoretical Analysis

MedKoo Cat#: 558821
Name: TAMRA alkyne, 6-isomer
CAS#: 1352649-44-5
Chemical Formula: C28H25N3O4
Exact Mass: 467.18
Molecular Weight: 467.530
Elemental Analysis: C, 71.93; H, 5.39; N, 8.99; O, 13.69

Price and Availability

Size Price Availability Quantity
5mg USD 390
25mg USD 700
50mg USD 1145
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Synonym: TAMRA alkyne, 6-isomer

IUPAC/Chemical Name: 2-(6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)-4-(prop-2-yn-1-ylcarbamoyl)benzoate


InChi Code: InChI=1S/C28H25N3O4/c1-6-13-29-27(32)17-7-10-20(28(33)34)23(14-17)26-21-11-8-18(30(2)3)15-24(21)35-25-16-19(31(4)5)9-12-22(25)26/h1,7-12,14-16H,13H2,2-5H3,(H-,29,32,33,34)

SMILES Code: CN(C)C1=CC=C(C(C2=C(C([O-])=O)C=CC(C(NCC#C)=O)=C2)=C3C=C/4)C(OC3=CC4=[N+](C)\C)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 467.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Rink, W.M.; Thomas, F. Decoration of Coiled-Coil Peptides with N-Cysteine Peptide Thioesters As Cyclic Peptide Precursors Using Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) Click Reaction. Organic Letters, 2018, 20(23), 7493–7497. doi: 10.1021/acs.orglett.8b03261