HTMT dimaleate
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MedKoo CAT#: 574084

CAS#: 195867-54-0(maleate)

Description: HTMT is a histamine H1 receptor agonist that binds to the histamine H4 receptor but does not increase calcium mobilization. HTMT increases intracellular calcium and inositol phosphate levels as well as proliferation of cholangiocytes.

Chemical Structure

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HTMT dimaleate
CAS# 195867-54-0(maleate)
Instruction

Theoretical Analysis

MedKoo Cat#: 574084
Name: HTMT dimaleate
CAS#: 195867-54-0(maleate)
Chemical Formula: C23H29F3N4O5
Exact Mass: 498.21
Molecular Weight: 498.500
Elemental Analysis: C, 55.42; H, 5.86; F, 11.43; N, 11.24; O, 16.05

Price and Availability

Size Price Availability Quantity
5mg USD 350 2 Weeks
10mg USD 600 2 Weeks
25mg USD 950 2 Weeks
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Synonym: Histamine trifluromethyl toluidine, HTMT

IUPAC/Chemical Name: 6-((2-(1H-imidazol-5-yl)ethyl)amino)-N-(4-(trifluoromethyl)phenyl)heptanamide dimaleate

InChi Key: ODAOZWTYNWZSBY-SPIKMXEPSA-N

InChi Code: InChI=1S/C19H25F3N4O.2C4H4O4/c1-14(24-11-10-17-12-23-13-25-17)4-2-3-5-18(27)26-16-8-6-15(7-9-16)19(20,21)22;2*5-3(6)1-2-4(7)8/h6-9,12-14,24H,2-5,10-11H2,1H3,(H,23,25)(H,26,27);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

SMILES Code: CC(NCCC1=CN=CN1)CCCCC(NC2=CC=C(C(F)(F)F)C=C2)=O.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 498.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Shayo, C., Fernandez, N., Legnazzi, B.L., et al. Histamine H2 receptor desensitization: Involvement of a select array of G protein-coupled receptor kinases. Mol. Pharmacol. 60(5), 1049-1056 (2001).

2. Zhu, Y., Michalovich, D., Wu, H., et al. Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol. Pharmacol. 59(3), 434-441 (2001).

3. Qiu, R., Melmon, K.L., and Kahn, M.M. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. J. Pharmacol. Exp. Ther. 253(3), 1245-1252 (1990).

4. Francis, H., Glaser, S., Demorrow, S., et al. Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway. Am. J. Physiol. Cell Physiol. 295(2), C499-C513 (2008).

5. Tripathi, T., Shahid, M., Khan, H.M., et al. Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists. Pharmacol. Rep. 62(5), 917-925 (2010).

6. Bell, J.K., McQueen, D.S., and Rees, J.L. Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in BalbC mice. Br. J. Pharmacol. 142(2), 374-380 (2004).