SS-208
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MedKoo CAT#: 408029

CAS#: 2245942-72-5

Description: SS-208 is a potent and selective HDAC6 inhibitor (IC50-12 nM). SS-208 showed Antitumor Activity in Syngeneic Melanoma Mouse Models. SS-208 induces minimal cell death and exhibits marginal effects on viability, cytotoxicity, and apoptosis, while significantly increasing the levels of Ac-α-Tubulin. SS-208 efficiently reduces the IL-6-mediated Y705 phosphorylation of STAT3 and downregulates the expression of PD-L1 at the mRNA levels in melanoma cells

Chemical Structure

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SS-208
CAS# 2245942-72-5
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 408029
Name: SS-208
CAS#: 2245942-72-5
Chemical Formula: C13H11Cl2N3O4
Exact Mass: 343.01
Molecular Weight: 344.150
Elemental Analysis: C, 45.37; H, 3.22; Cl, 20.60; N, 12.21; O, 18.60

Price and Availability

Size Price Availability Quantity
5mg USD 500 2 Weeks
10mg USD 850 2 Weeks
25mg USD 1350 2 Weeks
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Synonym: SS-208; SS 208; SS208;

IUPAC/Chemical Name: 5-(2-(3,4-Dichlorobenzamido)ethyl)-N-hydroxyisoxazole-3-carboxamide

InChi Key: JFGOILLZIAIYGA-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H11Cl2N3O4/c14-9-2-1-7(5-10(9)15)12(19)16-4-3-8-6-11(18-22-8)13(20)17-21/h1-2,5-6,21H,3-4H2,(H,16,19)(H,17,20)

SMILES Code: O=C(C1=NOC(CCNC(C2=CC=C(Cl)C(Cl)=C2)=O)=C1)NO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: SS-208 is a selective HDAC6 inhibitor with an IC50 of 12 nM.
In vitro activity: To be determined
In vivo activity: The findings of this study suggest that the antitumor activity of SS-208 is mainly mediated by immune-related antitumor activity. SS-208 had minimal effects on the viability of murine SM1 melanoma cells in vitro, but it significantly reduced in vivo tumor growth in a murine SM1 syngeneic melanoma mouse model. Reference: J Med Chem. 2019 Sep 26;62(18):8557-8577. https://pubmed.ncbi.nlm.nih.gov/31414801/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 125.0 363.21

Preparing Stock Solutions

The following data is based on the product molecular weight 344.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Shen S, Hadley M, Ustinova K, Pavlicek J, Knox T, Noonepalle S, Tavares MT, Zimprich CA, Zhang G, Robers MB, Bařinka C, Kozikowski AP, Villagra A. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 26;62(18):8557-8577. doi: 10.1021/acs.jmedchem.9b00946. Epub 2019 Sep 4. PMID: 31414801.
In vitro protocol: To be determined
In vivo protocol: 1. Shen S, Hadley M, Ustinova K, Pavlicek J, Knox T, Noonepalle S, Tavares MT, Zimprich CA, Zhang G, Robers MB, Bařinka C, Kozikowski AP, Villagra A. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 26;62(18):8557-8577. doi: 10.1021/acs.jmedchem.9b00946. Epub 2019 Sep 4. PMID: 31414801.

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1: Shen S, Hadley M, Ustinova K, Pavlicek J, Knox T, Noonepalle S, Tavares MT,
Zimprich CA, Zhang G, Robers MB, Bařinka C, Kozikowski AP, Villagra A. Discovery
of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208
with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep
4. doi: 10.1021/acs.jmedchem.9b00946. [Epub ahead of print] PubMed PMID:
31414801.