Psychotrine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585054

CAS#: 7633-29-6

Description: Psychotrine is a selective inhibitor of human immunodeficiency virus-1 reverse transcriptase.

Chemical Structure

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Psychotrine
CAS# 7633-29-6
Instruction

Theoretical Analysis

MedKoo Cat#: 585054
Name: Psychotrine
CAS#: 7633-29-6
Chemical Formula: C28H36N2O4
Exact Mass: 464.27
Molecular Weight: 464.606
Elemental Analysis: C, 72.39; H, 7.81; N, 6.03; O, 13.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Psychotrine

IUPAC/Chemical Name: Emetan-6'-ol, 1',2'-didehydro-7',10,11-trimethoxy-

InChi Key: NCALAYAMQHIWMN-REIDKSKDSA-N

InChi Code: InChI=1S/C28H36N2O4/c1-5-17-16-30-9-7-19-13-27(33-3)28(34-4)15-22(19)24(30)11-20(17)10-23-21-14-26(32-2)25(31)12-18(21)6-8-29-23/h12-15,17,20,24,31H,5-11,16H2,1-4H3/t17-,20-,24-/m0/s1

SMILES Code: CC[C@@H]1[C@@H](CC2=NCCC3=C2C=C(OC)C(O)=C3)C[C@H]4C5=C(C=C(OC)C(OC)=C5)CCN4C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 464.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tan GT, Kinghorn AD, Hughes SH, Pezzuto JM. Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase. J Biol Chem. 1991 Dec 15;266(35):23529-36. PubMed PMID: 1721050.

2: Itoh A, Ikuta Y, Baba Y, Tanahashi T, Nagakura N. Ipecac alkaloids from Cephaelis acuminata. Phytochemistry. 1999 Nov;52(6):1169-76. PubMed PMID: 10643674.

3: De Clercq E. Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. Med Res Rev. 2000 Sep;20(5):323-49. Review. PubMed PMID: 10934347.

4: Itoh A, Ikuta Y, Tanahashi T, Nagakura N. Two Alangium alkaloids from Alangium lamarckii. J Nat Prod. 2000 May;63(5):723-5. PubMed PMID: 10843602.

5: Ito A, Lee YH, Chai HB, Gupta MP, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. 1',2',3',4'-tetradehydrotubulosine, a cytotoxic alkaloid from Pogonopus speciosus. J Nat Prod. 1999 Sep;62(9):1346-8. PubMed PMID: 10514334.

6: Troconis M, Ma W, Nichols DE, McLaughlin J. Molecular modeling study of tubulosine and other related ipecac alkaloids. J Comput Aided Mol Des. 1998 Sep;12(5):411-8. PubMed PMID: 9834903.

7: Ma WW, Anderson JE, McKenzie AT, Byrn SR, McLaughlin JL, Hudson MS. Tubulosine: an antitumor constituent of Pogonopus speciosus. J Nat Prod. 1990 Jul-Aug;53(4):1009-14. PubMed PMID: 1982768.

8: Tan GT, Miller JF, Kinghorn AD, Hughes SH, Pezzuto JM. HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products. Biochem Biophys Res Commun. 1992 May 29;185(1):370-8. PubMed PMID: 1376118.