SA1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565786

CAS#: N/A

Description: SA1 is a novel pan-activator for all ampk isoforms


Chemical Structure

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SA1
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 565786
Name: SA1
CAS#: N/A
Chemical Formula: C27H22ClN5O4
Exact Mass: 515.136
Molecular Weight: 515.954
Elemental Analysis: C, 62.85; H, 4.30; Cl, 6.87; N, 13.57; O, 12.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SA1; SA 1; SA-1

IUPAC/Chemical Name: (3R,3aR,6R,6aR)-6-((5-(4'-(1H-pyrazol-1-yl)-[1,1'-biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

InChi Key: REWNBDZXSVVXBZ-WMMXXEOUSA-N

InChi Code: InChI=1S/C27H22ClN5O4/c28-19-12-20-26(32-27(30-20)37-22-14-36-24-21(34)13-35-25(22)24)31-23(19)17-4-2-15(3-5-17)16-6-8-18(9-7-16)33-11-1-10-29-33/h1-12,21-22,24-25,34H,13-14H2,(H,30,31,32)/t21-,22-,24-,25-/m1/s1

SMILES Code: O[C@H]1[C@](OC[C@H]2OC3=NC4=NC(C5=CC=C(C6=CC=C(N7N=CC=C7)C=C6)C=C5)=C(Cl)C=C4N3)([H])[C@]2([H])OC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 515.954 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, Kaur P, Miao W, Gurgel G, You C, Piehler J, Kad NM, Riehn R, Opresko PL, Smith S, Tao YJ, Wang H. Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing. Nucleic Acids Res. 2016 Jul 27;44(13):6363-76. doi: 10.1093/nar/gkw518. Epub 2016 Jun 13. PubMed PMID: 27298259; PubMed Central PMCID: PMC5291270.

2: Wali RK, Momi N, Dela Cruz M, Calderwood AH, Stypula-Cyrus Y, Almassalha L, Chhaparia A, Weber CR, Radosevich A, Tiwari AK, Latif B, Backman V, Roy HK. Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications. Cancer Prev Res (Phila). 2016 Nov;9(11):844-854. Epub 2016 Aug 22. PubMed PMID: 27549371; PubMed Central PMCID: PMC5093027.

3: Valerio D, Luddi A, De Leo V, Labella D, Longobardi S, Piomboni P. SA1/SA2 cohesion proteins and SIRT1-NAD+ deacetylase modulate telomere homeostasis in cumulus cells and are eligible biomarkers of ovarian aging. Hum Reprod. 2018 May 1;33(5):887-894. doi: 10.1093/humrep/dey035. PubMed PMID: 29481647.

4: Fan J, Zeng Z, Mai K, Yang Y, Feng J, Bai Y, Sun B, Xie Q, Tong Y, Ma J. Preliminary treatment of bovine mastitis caused by Staphylococcus aureus, with trx-SA1, recombinant endolysin of S. aureus bacteriophage IME-SA1. Vet Microbiol. 2016 Aug 15;191:65-71. doi: 10.1016/j.vetmic.2016.06.001. Epub 2016 Jun 6. PubMed PMID: 27374909.

5: Hegedűs B, Kós PB, Bálint B, Maróti G, Gan HM, Perei K, Rákhely G. Complete genome sequence of Novosphingobium resinovorum SA1, a versatile xenobiotic-degrading bacterium capable of utilizing sulfanilic acid. J Biotechnol. 2017 Jan 10;241:76-80. doi: 10.1016/j.jbiotec.2016.11.013. Epub 2016 Nov 13. PubMed PMID: 27851894.

6: Cuadrado A, Remeseiro S, Graña O, Pisano DG, Losada A. The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues. Nucleic Acids Res. 2015 Mar 31;43(6):3056-67. doi: 10.1093/nar/gkv144. Epub 2015 Mar 3. PubMed PMID: 25735743; PubMed Central PMCID: PMC4381060.

7: Kojic A, Cuadrado A, De Koninck M, Giménez-Llorente D, Rodríguez-Corsino M, Gómez-López G, Le Dily F, Marti-Renom MA, Losada A. Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization. Nat Struct Mol Biol. 2018 Jun;25(6):496-504. doi: 10.1038/s41594-018-0070-4. Epub 2018 Jun 4. PubMed PMID: 29867216; PubMed Central PMCID: PMC6122591.

8: Jones CM, Griffiths PC, Mellalieu SD. Training Load and Fatigue Marker Associations with Injury and Illness: A Systematic Review of Longitudinal Studies. Sports Med. 2017 May;47(5):943-974. doi: 10.1007/s40279-016-0619-5. Review. PubMed PMID: 27677917; PubMed Central PMCID: PMC5394138.

9: Kong X, Ball AR Jr, Pham HX, Zeng W, Chen HY, Schmiesing JA, Kim JS, Berns M, Yokomori K. Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. Mol Cell Biol. 2014 Feb;34(4):685-98. doi: 10.1128/MCB.01503-13. Epub 2013 Dec 9. PubMed PMID: 24324008; PubMed Central PMCID: PMC3911484.

10: Eddolls WTB, McNarry MA, Stratton G, Winn CON, Mackintosh KA. High-Intensity Interval Training Interventions in Children and Adolescents: A Systematic Review. Sports Med. 2017 Nov;47(11):2363-2374. doi: 10.1007/s40279-017-0753-8. Review. PubMed PMID: 28643209; PubMed Central PMCID: PMC5633633.

11: Burger NFV, Venter E, Botha AM. Profiling Diuraphis noxia (Hemiptera: Aphididae) Transcript Expression of the Biotypes SA1 and SAM Feeding on Various Triticum aestivum Varieties. J Econ Entomol. 2017 Apr 1;110(2):692-701. doi: 10.1093/jee/tow313. PubMed PMID: 28334389.

12: Hegedüs B, Kós PB, Bende G, Bounedjoum N, Maróti G, Laczi K, Szuhaj M, Perei K, Rákhely G. Starvation- and xenobiotic-related transcriptomic responses of the sulfanilic acid-degrading bacterium, Novosphingobium resinovorum SA1. Appl Microbiol Biotechnol. 2018 Jan;102(1):305-318. doi: 10.1007/s00253-017-8553-5. Epub 2017 Oct 19. PubMed PMID: 29051988.

13: Bisht KK, Daniloski Z, Smith S. SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres. J Cell Sci. 2013 Aug 1;126(Pt 15):3493-503. doi: 10.1242/jcs.130872. Epub 2013 May 31. PubMed PMID: 23729739; PubMed Central PMCID: PMC3730250.

14: Ash C, Town G, Whittall R, Tooze L, Phillips J. Lasers and intense pulsed light (IPL) association with cancerous lesions. Lasers Med Sci. 2017 Nov;32(8):1927-1933. doi: 10.1007/s10103-017-2310-y. Epub 2017 Sep 7. Review. PubMed PMID: 28884244; PubMed Central PMCID: PMC5653718.

15: Lindh E, Brännström J, Jones P, Wermeling F, Hässler S, Betterle C, Garty BZ, Stridsberg M, Herrmann B, Karlsson MC, Winqvist O. Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1. J Autoimmun. 2013 May;42:1-6. doi: 10.1016/j.jaut.2012.10.001. Epub 2012 Nov 1. PubMed PMID: 23122533.

16: Park SW, Lee CH, Shin DH, Bang NS, Lee SM. Effect of SA1, a herbal formulation, on sexual behavior and penile erection. Biol Pharm Bull. 2006 Jul;29(7):1383-6. PubMed PMID: 16819173.

17: Zhang N, Jiang Y, Mao Q, Demeler B, Tao YJ, Pati D. Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. PLoS One. 2013 Jul 12;8(7):e69458. doi: 10.1371/journal.pone.0069458. Print 2013. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/69ab23f6-7d99-4098-85ca-999da9093ec8. PubMed PMID: 23874961; PubMed Central PMCID: PMC3709894.

18: Feng X, Xiong J, Lu Y, Xia X, Zhu MX. Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1. Cell Calcium. 2014 Dec;56(6):446-56. doi: 10.1016/j.ceca.2014.09.004. Epub 2014 Sep 19. PubMed PMID: 25266962; PubMed Central PMCID: PMC4252876.

19: Ngugi DK, Stingl U. High-Quality Draft Single-Cell Genome Sequence Belonging to the Archaeal Candidate Division SA1, Isolated from Nereus Deep in the Red Sea. Genome Announc. 2018 May 10;6(19). pii: e00383-18. doi: 10.1128/genomeA.00383-18. PubMed PMID: 29748404; PubMed Central PMCID: PMC5946040.

20: Bensmaïa SJ, Craig JC, Yoshioka T, Johnson KO. SA1 and RA afferent responses to static and vibrating gratings. J Neurophysiol. 2006 Mar;95(3):1771-82. Epub 2005 Oct 19. PubMed PMID: 16236779; PubMed Central PMCID: PMC1839046.