Methyl decanoate
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MedKoo CAT#: 581924

CAS#: 110-42-9

Description: Methyl decanoate is an unsaturated biodiesel fuel surrogate. It can also be used as flavor and fragrance ingredients.

Chemical Structure

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Methyl decanoate
CAS# 110-42-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 581924
Name: Methyl decanoate
CAS#: 110-42-9
Chemical Formula: C11H22O2
Exact Mass: 186.16
Molecular Weight: 186.295
Elemental Analysis: C, 70.92; H, 11.90; O, 17.18

Price and Availability

Size Price Availability Quantity
100g USD 450 2 weeks
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Synonym: Methyl decanoate; Capric acid methyl ester; Decanoic acid, methyl ester; Methyl caprate; Methyl caprinate; Methyl n-caprate; Methyl n-decanoate; Methyl-n-caprate

IUPAC/Chemical Name: methyl decanoate

InChi Key: YRHYCMZPEVDGFQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H22O2/c1-3-4-5-6-7-8-9-10-11(12)13-2/h3-10H2,1-2H3

SMILES Code: C(CCCCCCCC)C(=O)OC

Appearance: Liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Methyl decanoate is an unsaturated biodiesel fuel surrogate.
In vitro activity: This study utilizes this model to analyze a role for MCFAs in regulating autophagy. This study shows that treatment with decanoic acid but not octanoic acid induces autophagosome formation and modulates autophagic flux in high glucose conditions. To investigate this effect, decanoic acid, but not octanoic acid, was found to induce the expression of autophagy-inducing proteins (Atg1 and Atg8), providing a mechanism for this effect. Reference: Cells. 2021 Oct 29;10(11):2946. https://pubmed.ncbi.nlm.nih.gov/34831171/
In vivo activity: DA (decanoic acid) inhibited the mean firing frequency of both TG and SpVc NS neurons, reaching a maximum inhibition of discharge frequency within 1-5 minutes and reversing after approximately 10-minutes; however, this DA-induced suppression of SpVc NS neuronal firing frequency did not occur in rats administered with methoctramine intravenously prior to stimulation. Reference: J Pain Res. 2018 Nov 14;11:2867-2876. https://pubmed.ncbi.nlm.nih.gov/30532581/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 25.0 134.20

Preparing Stock Solutions

The following data is based on the product molecular weight 186.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Warren EC, Kramár P, Lloyd-Jones K, Williams RSB. Decanoic Acid Stimulates Autophagy in D. discoideum. Cells. 2021 Oct 29;10(11):2946. doi: 10.3390/cells10112946. PMID: 34831171; PMCID: PMC8616062. 2. Andersen JV, Westi EW, Jakobsen E, Urruticoechea N, Borges K, Aldana BI. Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply. Mol Brain. 2021 Sep 3;14(1):132. doi: 10.1186/s13041-021-00842-2. PMID: 34479615; PMCID: PMC8414667. 3. Nakajima R, Uehara A, Takehana S, Akama Y, Shimazu Y, Takeda M. Decanoic acid attenuates the excitability of nociceptive trigeminal primary and secondary neurons associated with hypoalgesia. J Pain Res. 2018 Nov 14;11:2867-2876. doi: 10.2147/JPR.S181032. PMID: 30532581; PMCID: PMC6241697. 4. Noguchi Y, Matsuzawa N, Akama Y, Sekiguchi K, Takehana S, Shimazu Y, Takeda M. Dietary constituent, decanoic acid suppresses the excitability of nociceptive trigeminal neuronal activity associated with hypoalgesia via muscarinic M2 receptor signaling. Mol Pain. 2017 Jan-Dec;13:1744806917710779. doi: 10.1177/1744806917710779. PMID: 28474958; PMCID: PMC5448867.
In vitro protocol: 1. Warren EC, Kramár P, Lloyd-Jones K, Williams RSB. Decanoic Acid Stimulates Autophagy in D. discoideum. Cells. 2021 Oct 29;10(11):2946. doi: 10.3390/cells10112946. PMID: 34831171; PMCID: PMC8616062. 2. Andersen JV, Westi EW, Jakobsen E, Urruticoechea N, Borges K, Aldana BI. Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply. Mol Brain. 2021 Sep 3;14(1):132. doi: 10.1186/s13041-021-00842-2. PMID: 34479615; PMCID: PMC8414667.
In vivo protocol: 1. Nakajima R, Uehara A, Takehana S, Akama Y, Shimazu Y, Takeda M. Decanoic acid attenuates the excitability of nociceptive trigeminal primary and secondary neurons associated with hypoalgesia. J Pain Res. 2018 Nov 14;11:2867-2876. doi: 10.2147/JPR.S181032. PMID: 30532581; PMCID: PMC6241697. 2. Noguchi Y, Matsuzawa N, Akama Y, Sekiguchi K, Takehana S, Shimazu Y, Takeda M. Dietary constituent, decanoic acid suppresses the excitability of nociceptive trigeminal neuronal activity associated with hypoalgesia via muscarinic M2 receptor signaling. Mol Pain. 2017 Jan-Dec;13:1744806917710779. doi: 10.1177/1744806917710779. PMID: 28474958; PMCID: PMC5448867.

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3: Meng Q, Chi Y, Zhang L, Zhang P, Sheng L. Towards high-level theoretical studies of large biodiesel molecules: an ONIOM/RRKM/Master-equation approach to the isomerization and dissociation kinetics of methyl decanoate radicals. Phys Chem Chem Phys. 2019 Feb 27;21(9):5232-5242. doi: 10.1039/c8cp05593a. PubMed PMID: 30775733.

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8: Schmidt M, Deckwerth J, Schomäcker R, Schwarze M. Alkaline Hydrolysis of Methyl Decanoate in Surfactant-Based Systems. J Org Chem. 2018 Jul 20;83(14):7398-7406. doi: 10.1021/acs.joc.8b00247. Epub 2018 May 23. PubMed PMID: 29762024.

9: Sugiharto YEC, Lee H, Fitriana AD, Lee H, Jeon W, Park K, Ahn J, Lee H. Effect of decanoic acid and 10-hydroxydecanoic acid on the biotransformation of methyl decanoate to sebacic acid. AMB Express. 2018 May 5;8(1):75. doi: 10.1186/s13568-018-0605-4. PubMed PMID: 29730843; PubMed Central PMCID: PMC5936482.

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