OPC 28326

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584924

CAS#: 167621-24-1

Description: OPC 28326 is a selective peripheral vasodilator with angiogenic activity that mitigates postinfarction cardiac remodeling.

Chemical Structure

img
OPC 28326
CAS# 167621-24-1
Instruction

Theoretical Analysis

MedKoo Cat#: 584924
Name: OPC 28326
CAS#: 167621-24-1
Chemical Formula: C26H36ClN3O2
Exact Mass: 457.25
Molecular Weight: 458.043
Elemental Analysis: C, 68.18; H, 7.92; Cl, 7.74; N, 9.17; O, 6.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: OPC 28326; OPC-28326; OPC28326

IUPAC/Chemical Name: Propanamide, N-(2,6-dimethyl-4-((4-(methyl(2-phenylethyl)amino)-1-piperidinyl)carbonyl)phenyl)-, monohydrochloride

InChi Key: ADNUSXMBYGPKTH-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H35N3O2.ClH/c1-5-24(30)27-25-19(2)17-22(18-20(25)3)26(31)29-15-12-23(13-16-29)28(4)14-11-21-9-7-6-8-10-21;/h6-10,17-18,23H,5,11-16H2,1-4H3,(H,27,30);1H

SMILES Code: CCC(NC1=C(C)C=C(C(N2CCC(N(C)CCC3=CC=CC=C3)CC2)=O)C=C1C)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 458.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ogino A, Takemura G, Hashimoto A, Kanamori H, Okada H, Nakagawa M, Tsujimoto A, Goto K, Kawasaki M, Nagashima K, Miyakoda G, Fujiwara T, Yabuuchi Y, Fujiwara H, Minatoguchi S. OPC-28326, a selective peripheral vasodilator with angiogenic activity, mitigates postinfarction cardiac remodeling. Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H213-21. doi: 10.1152/ajpheart.00062.2015. Epub 2015 Apr 24. PubMed PMID: 25910803.

2: Sumi M, Sata M, Hashimoto A, Imaizumi T, Yanaga K, Ohki T, Mori T, Nagai R. OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis. Biomed Pharmacother. 2007 May;61(4):209-15. Epub 2006 Dec 28. PubMed PMID: 17223008.

3: Sun B, Lockyer S, Li J, Chen R, Yoshitake M, Kambayashi JI. OPC-28326, a selective femoral vasodilator, is an alpha2C-adrenoceptor-selective antagonist. J Pharmacol Exp Ther. 2001 Nov;299(2):652-8. PubMed PMID: 11602678.

4: Orito K, Imaizumi T, Yoshida K, Fujiki H, Kishi M, Teramoto S, Tanaka M, Shimizu H, Tominaga M, Kimura Y, Kambayashi J, Mori T. Mechanisms of action of OPC-28326, a selective hindlimb vasodilator. J Pharmacol Exp Ther. 1999 Nov;291(2):604-11. PubMed PMID: 10525078.

5: Orito K, Kishi M, Imaizumi T, Nakazawa T, Hashimoto A, Mori T, Kambe T. alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. Br J Pharmacol. 2001 Oct;134(4):763-70. PubMed PMID: 11606316; PubMed Central PMCID: PMC1573002.

6: Orito K, Imaizumi T, Yoshida K, Kishi M, Fujiki H, Mori T. Effect of oral OPC-28326, a selective femoral arterial vasodilator, on hindlimb subcutaneous tissue temperature in conscious dogs under buprenorphine sedation. Jpn J Pharmacol. 2002 Jan;88(1):119-22. PubMed PMID: 11855671.

7: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Jan-Feb;26(1):53-84. Review. PubMed PMID: 14988742.

8: Fukui D, Yang XP, Chiba S. Neurogenic double-peaked vasoconstriction of human gastroepiploic artery is mediated by both alpha1- and alpha2-adrenoceptors. Br J Pharmacol. 2005 Mar;144(6):737-42. PubMed PMID: 15685216; PubMed Central PMCID: PMC1576054.

9: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Dec;25(10):831-55. PubMed PMID: 14735233.

10: Wise RA, Wigley FM, White B, Leatherman G, Zhong J, Krasa H, Kambayashi J, Orlandi C, Czerwiec FS. Efficacy and tolerability of a selective alpha(2C)-adrenergic receptor blocker in recovery from cold-induced vasospasm in scleroderma patients: a single-center, double-blind, placebo-controlled, randomized crossover study. Arthritis Rheum. 2004 Dec;50(12):3994-4001. PubMed PMID: 15593189.

11: Mehrotra S, Gupta S, Garrelds IM, Villalón CM, Saxena PR, Bogers AJ, Maassenvandenbrink A. Effects of current and prospective antimigraine drugs on the porcine isolated meningeal artery. Naunyn Schmiedebergs Arch Pharmacol. 2006 Dec;374(3):163-75. Epub 2006 Nov 14. PubMed PMID: 17103145.

12: Robins P. Japanese Pharmacological Society--77th Annual Meeting. Part I. 8-10 March 2004, Osaka, Japan. IDrugs. 2004 Apr;7(4):295-7. PubMed PMID: 15057628.