Chlorfluazuron | CAS# 71422-67-8 | Chitin Synthesis Inhibitor

Chlorfluazuron
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573539

CAS#: 71422-67-8

Description: Chlorfluazuron is a chitin synthesis inhibitor. Chlorfluazuron is commonly used in agriculture as an insect growth regulator for controlling the major insect pests in crops

Chemical Structure

Chlorfluazuron

CAS# 71422-67-8

Instruction

Theoretical Analysis

MedKoo Cat#: 573539
Name: Chlorfluazuron
CAS#: 71422-67-8
Chemical Formula: C20H9Cl3F5N3O3
Exact Mass: 538.96
Molecular Weight: 540.650
Elemental Analysis: C, 44.43; H, 1.68; Cl, 19.67; F, 17.57; N, 7.77; O, 8.88

Price and Availability

Size	Price	Availability
50mg	USD 350	2 Weeks
1g	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: AI3-29785, Atabron, CCRIS 2680, CGA 112913, Chlorfluazuron, IKI 7899, PP 145, UC 62644

IUPAC/Chemical Name: Benzamide, N-(((3,5-dichloro-4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenyl)amino)carbonyl)-2,6-difluoro-

InChi Key: UISUNVFOGSJSKD-UHFFFAOYSA-N

InChi Code: 1S/C20H9Cl3F5N3O3/c21-10-5-9(30-19(33)31-17(32)15-13(24)2-1-3-14(15)25)6-11(22)16(10)34-18-12(23)4-8(7-29-18)20(26,27)28/h1-7H,(H2,30,31,32,33)

SMILES Code: c1cc(c(c(c1)F)C(=O)NC(=O)Nc2cc(c(c(c2)Cl)Oc3c(cc(cn3)C(F)(F)F)Cl)Cl)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 540.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Li H, Zhong Q, Wang X, Luo F, Zhou L, Sun H, Yang M, Lou Z, Chen Z, Zhang X. The degradation and metabolism of chlorfluazuron and flonicamid in tea: A risk assessment from tea garden to cup. Sci Total Environ. 2021 Feb 1;754:142070. doi: 10.1016/j.scitotenv.2020.142070. Epub 2020 Aug 29. PMID: 32920390.

2: Cho S, Kim J, Lee S, Kim TH. Crystal structure of chlorfluazuron. Acta Crystallogr E Crystallogr Commun. 2015 Jan 1;71(Pt 1):o55. doi: 10.1107/S2056989014026632. PMID: 25705506; PMCID: PMC4331875.

3: Wan Umar WAS, Ab Majid AH. Efficacy of Minimum Application of Chlorfluazuron Baiting to Control Urban Subterranean Termite Populations of Coptotermes gestroi (Wasmann) (Blattodea: Rhinotermitidae). Insects. 2020 Aug 25;11(9):569. doi: 10.3390/insects11090569. PMID: 32854188; PMCID: PMC7564584.

4: Huang Q, Wu X, Yu X, Zhang L, Lu M, Tao L. Comparison of the cytotoxic impact of chlorfluazuron on selected insect and human cell lines. Environ Toxicol Chem. 2015 Jul;34(7):1675-82. doi: 10.1002/etc.2969. Epub 2015 May 14. PMID: 25753780.

5: Ganguly P, Barik SR, Patra S, Roy S, Bhattacharyya A. Persistence of chlorfluazuron in cabbage under different agro-climatic conditions of India and its risk assessment. Environ Toxicol Chem. 2017 Nov;36(11):3028-3033. doi: 10.1002/etc.3872. Epub 2017 Jul 17. PMID: 28574603.

6: Sun M, Tong Z, Dong X, Chu Y, Wang M, Gao T, Duan J. Determination of the Residue Behavior and Risk Assessment of Chlorfluazuron in Chinese Cabbage, Kale, Lettuce and Cauliflower by UPLC-MS/MS. Int J Environ Res Public Health. 2019 May 17;16(10):1758. doi: 10.3390/ijerph16101758. PMID: 31108982; PMCID: PMC6571697.

7: Guo HF, Fang JC, Liu BS, Wang JP, Zhong WF, Wan FH. Enhancement of the biological activity of nucleopolyhedrovirus through disruption of the peritrophic matrix of insect larvae by chlorfluazuron. Pest Manag Sci. 2007 Jan;63(1):68-74. doi: 10.1002/ps.1316. PMID: 17103370.

8: Hussein HS, Eldesouky SE. Insecticidal, Behavioral and Biological Effects of Chlorantraniliprole and Chlorfluazuron on Cotton Leafworm (Spodoptera littoralis). Pak J Biol Sci. 2019 Jan;22(8):372-382. doi: 10.3923/pjbs.2019.372.382. PMID: 31930825.

9: Zhang P, Zhao YH, Wang QH, Mu W, Liu F. Lethal and sublethal effects of the chitin synthesis inhibitor chlorfluazuron on Bradysia odoriphaga Yang and Zhang (Diptera: Sciaridae). Pestic Biochem Physiol. 2017 Mar;136:80-88. doi: 10.1016/j.pestbp.2016.07.007. Epub 2016 Jul 26. PMID: 28187835.

10: Rabea EI, Nasr HM, Badawy ME. Toxic effect and biochemical study of chlorfluazuron, oxymatrine, and spinosad on honey bees (Apis mellifera). Arch Environ Contam Toxicol. 2010 Apr;58(3):722-32. doi: 10.1007/s00244-009-9403-y. Epub 2009 Oct 8. PMID: 19812878.

11: Shim JH, Abd El-Aty AM, Choi JH, Choi YS. Post-harvest HPLC determination of chlorfluazuron residues in pears treated with different programs. Biomed Chromatogr. 2007 Jul;21(7):695-700. doi: 10.1002/bmc.807. PMID: 17428007.

12: Choi JH, Mamun MI, Park JH, Shin EH, Shim JH. Determination of field- incurred chlorfluazuron residues in the peach. Bull Environ Contam Toxicol. 2011 Mar;86(3):331-5. doi: 10.1007/s00128-011-0191-5. Epub 2011 Feb 15. PMID: 21327612.

13: Manzoor F, Pervez M. Evaluation of Chlorfluazuron Against Subterranean Termites Heterotermes indicola (Isoptera: Rhinotermitidae) in Pakistan. J Econ Entomol. 2016 Dec 1;109(6):2264-2271. doi: 10.1093/jee/tow211. PMID: 27744282.

14: Rust MK, Hemsarth WL. Intrinsic Activity of IGRs Against Larval Cat Fleas. J Med Entomol. 2017 Mar 1;54(2):418-421. doi: 10.1093/jme/tjw201. PMID: 28011733.

15: Spence SA, Murison R, Harden S. Rate of decline of chlorfluazuron concentration in the fat of cattle. Aust Vet J. 1998 Jan;76(1):54-6. doi: 10.1111/j.1751-0813.1998.tb15687.x. PMID: 9578769.

16: Lee CC, Neoh KB, Lee CY. Colony Size Affects the Efficacy of Bait Containing Chlorfluazuron Against the Fungus-Growing Termite Macrotermes gilvus (Blattodea: Termitidae). J Econ Entomol. 2014 Dec;107(6):2154-62. doi: 10.1603/EC14193. PMID: 26470081.

17: Quesada BL, Montoya-Lerma J. Laboratory evaluation of chlorfluazuron against larval phlebotomine sand flies (Diptera: Psychodidae). J Econ Entomol. 1994 Oct;87(5):1129-32. doi: 10.1093/jee/87.5.1129. PMID: 7962946.

18: Peters BC, Fitzgerald CJ. Field evaluation of the bait toxicant chlorfluazuron in eliminating Coptotermes acinaciformis (Froggatt) (Isoptera: Rhinotermitidae). J Econ Entomol. 2003 Dec;96(6):1828-31. doi: 10.1093/jee/96.6.1828. PMID: 14977122.

19: Armishaw P, Ward J, Millar RG. Development of a reference material for residues of chlorfluazuron and fluazuron in beef fat ACSL CRM 3Part I. Preparation, homogeneity and stabilit. Anal Bioanal Chem. 1996 Aug;356(1):10-2. doi: 10.1007/s0021663560010. PMID: 15045250.

20: Wang J, Zheng X, Yuan J, Wang S, Xu B, Wang S, Zhang Y, Wu Q. Insecticide Resistance Monitoring of the Diamondback Moth (Lepidoptera: Plutellidae) Populations in China. J Econ Entomol. 2021 Jun 11;114(3):1282-1290. doi: 10.1093/jee/toab027. PMID: 33728433.

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