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MedKoo CAT#: 584883

CAS#: 1845-11-0

Description: Nafoxidine is an estrogen antagonist that has been used in the treatment of breast cancer.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-11. Prices are subject to change without notice.

Nafoxidine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 584883
Name: Nafoxidine
CAS#: 1845-11-0
Chemical Formula: C29H31NO2
Exact Mass: 425.2355
Molecular Weight: 425.572
Elemental Analysis: C, 81.85; H, 7.34; N, 3.29; O, 7.52

Synonym: Nafoxidine

IUPAC/Chemical Name: Pyrrolidine, 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-


InChi Code: InChI=1S/C29H31NO2/c1-31-26-14-16-28-24(21-26)11-15-27(22-7-3-2-4-8-22)29(28)23-9-12-25(13-10-23)32-20-19-30-17-5-6-18-30/h2-4,7-10,12-14,16,21H,5-6,11,15,17-20H2,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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7: Devi PK. Antiestrogens. Pharmacol Ther. 1981;12(3):439-47. Review. PubMed PMID: 7025028.

8: Maertens C, Droogmans G, Chakraborty P, Nilius B. Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine. Br J Pharmacol. 2001 Jan;132(1):135-42. PubMed PMID: 11156570; PubMed Central PMCID: PMC1572544.

9: Campbell PS, Satterfield PM. Effect of neonatal exposure to the antioestrogens nafoxidine and CI-628 upon the development of the uterus in the prepubertal rat. J Reprod Fertil. 1988 May;83(1):225-31. PubMed PMID: 3397940.

10: Santa Cruz AR, Medrano EE, Baldi A. Dolichol-sugar derivative synthesis in human breast cancer cell line (T47D). Effects of estrogens and antiestrogens. Biochem Biophys Res Commun. 1985 Jan 16;126(1):382-8. PubMed PMID: 3970700.

11: De Lorenzo MS, Farina HG, Alonso DF, Gomez DE. Role of protein kinase C-dependent signaling pathways in the antiangiogenic properties of nafoxidine. Anticancer Res. 2004 May-Jun;24(3a):1737-43. PubMed PMID: 15274349.

12: Gray JM, Wade GN. Food intake, body weight, and adiposity in female rats: actions and interactions of progestins and antiestrogens. Am J Physiol. 1981 May;240(5):E474-81. PubMed PMID: 7195153.

13: Yaz G, Kabadere S, Oztopçu P, Durmaz R, Uyar R. Comparison of the antiproliferative properties of antiestrogenic drugs (nafoxidine and clomiphene) on glioma cells in vitro. Am J Clin Oncol. 2004 Aug;27(4):384-8. PubMed PMID: 15289732.

14: Galand P, Tchernitchin N, Tchernitchin AN. Time-course of the effects of nafoxidine and oestradiol on separate groups of responses in the uterus of the immature rat. J Steroid Biochem. 1984 Jul;21(1):43-7. PubMed PMID: 6748655.

15: Alhadi T, Vonderhaar BK. Induction of cryptic lactogenic hormone binding in livers of adult female mice treated neonatally with estradiol or nafoxidine. Endocrinology. 1982 Jan;110(1):254-9. PubMed PMID: 6274621.

16: Trachtenberg J. Androgen receptor content of nafoxidine treated experimentally induced canine prostatic hyperplasia. Clin Invest Med. 1985;8(1):29-34. PubMed PMID: 2580656.

17: Chan L, Jackson RL, Means AR. Female steroid hormones and lipoprotein synthesis in the cockerel: effects of progesterone and nafoxidine on the estrogenic stimulation of very low density lipoproteins (VLDL) synthesis. Endocrinology. 1977 Jun;100(6):1636-43. PubMed PMID: 192542.

18: Gardner RM, Kirkland JL, Stancel GM. Selective blockade of estrogen-induced uterine responses by the antiestrogen nafoxidine. Endocrinology. 1978 Nov;103(5):1583-9. PubMed PMID: 748005.

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20: Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997 Mar;138(3):863-70. PubMed PMID: 9048584.