SST-02

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555496

CAS#: 1534346-00-3

Description: SST-02 is a potent cationic lipid for siRNA-Lipid Nanoparticles. SST-02 possesses a simple chemical structure and is synthesized just in one step. SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats administered with 3 mg/kg of SST-02 LNP did not show changes in body weight, blood chemistry, or hematological parameters, while the AST level decreased at a dose of 5 mg/kg. The use of SST-02 avoids a lengthy synthetic route and may thus decrease the future cost of nucleic acid therapeutics.

Chemical Structure

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SST-02
CAS# 1534346-00-3
Instruction

Theoretical Analysis

MedKoo Cat#: 555496
Name: SST-02
CAS#: 1534346-00-3
Chemical Formula: C39H73NO
Exact Mass: 571.57
Molecular Weight: 572.019
Elemental Analysis: C, 81.89; H, 12.86; N, 2.45; O, 2.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SST-02; SST 02; SST02;

IUPAC/Chemical Name: 3-(di((9Z,12Z)-octadeca-9,12-dien-1-yl)amino)propan-1-ol

InChi Key: SGQSGJUTBKNKIB-MAZCIEHSSA-N

InChi Code: InChI=1S/C39H73NO/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-40(38-35-39-41)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h11-14,17-20,41H,3-10,15-16,21-39H2,1-2H3/b13-11-,14-12-,19-17-,20-18-

SMILES Code: CCCCC/C=C\C/C=C\CCCCCCCCN(CCCO)CCCCCCCC/C=C\C/C=C\CCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Cationic lipids are key components of siRNA-lipid nanoparticles (LNP), which may serve as potential therapeutic agents for various diseases. For a decade, chemists have given enhanced potency and new functions to cationic lipids along with structural complexity.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 572.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles
Takeshi Kuboyama, Kaori Yagi, Tomoyuki Naoi, Tomohiro Era, Nobuhiro Yagi, Yoshisuke Nakasato, Hayato Yabuuchi, Saori Takahashi, Fumikazu Shinohara, Hiroto Iwai, Ayumi Koubara-Yamada, Kazumasa Hasegawa, and Atsushi Miwa
Publication Date (Web): April 12, 2019 (Letter)
DOI: 10.1021/acsmedchemlett.8b00652