FKGK18
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555454

CAS#: 1071001-09-6

Description: FKGK18 is the most potent inhibitor of GVIA iPLA(2) (X(I)(50) = 0.0002) ever reported. Being 195 and >455 times more potent for GVIA iPLA(2) than for GIVA cPLA(2) and GV sPLA(2), respectively. Group VIA calcium-independent phospholipase A(2) (GVIA iPLA(2)) has recently emerged as a novel pharmaceutical target.

Chemical Structure

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FKGK18
CAS# 1071001-09-6
Instruction

Theoretical Analysis

MedKoo Cat#: 555454
Name: FKGK18
CAS#: 1071001-09-6
Chemical Formula: C16H15F3O
Exact Mass: 280.11
Molecular Weight: 280.290
Elemental Analysis: C, 68.56; H, 5.39; F, 20.33; O, 5.71

Price and Availability

Size Price Availability Quantity
10mg USD 350
50mg USD 1050
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Synonym: FKGK18; FKGK-18; FKGK 18;

IUPAC/Chemical Name: 1,1,1-Trifluoro-6-(2-naphthalenyl)-2-hexanone

InChi Key: VCWWTQMRNJSJGC-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H15F3O/c17-16(18,19)15(20)8-4-1-5-12-9-10-13-6-2-3-7-14(13)11-12/h2-3,6-7,9-11H,1,4-5,8H2

SMILES Code: O=C(CCCCC1=CC=C2C=CC=CC2=C1)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 280.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bone RN, Gai Y, Magrioti V, Kokotou MG, Ali T, Lei X, Tse HM, Kokotos G,
Ramanadham S. Inhibition of Ca2+-independent phospholipase A2β (iPLA2β)
ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes.
2015 Feb;64(2):541-54. doi: 10.2337/db14-0097. Epub 2014 Sep 11. PubMed PMID:
25213337; PubMed Central PMCID: PMC4303959.


2: Ali T, Kokotos G, Magrioti V, Bone RN, Mobley JA, Hancock W, Ramanadham S.
Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent
phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and
diabetes. PLoS One. 2013 Aug 20;8(8):e71748. doi: 10.1371/journal.pone.0071748.
eCollection 2013. PubMed PMID: 23977134; PubMed Central PMCID: PMC3748103.


3: Kokotos G, Hsu YH, Burke JE, Baskakis C, Kokotos CG, Magrioti V, Dennis EA.
Potent and selective fluoroketone inhibitors of group VIA calcium-independent
phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. doi: 10.1021/jm901872v.
PubMed PMID: 20369880; PubMed Central PMCID: PMC2865582.