TTT20171

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407978

CAS#: 2110408-47-2

Description: TTT20171 is a SDHC inhibitor. TTT20171 displays nanomolar inhibition of CII but lacks cellular potency. In cell assays, the most sensitive cells (22Rv1 prostate cancer cells) are inhibited at an IC50=5.4 uM, a value well above the suggested use concentration of 2 uM and the criterion of 1 uM for a quality chemical probe.

Chemical Structure

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TTT20171
CAS# 2110408-47-2
Instruction

Theoretical Analysis

MedKoo Cat#: 407978
Name: TTT20171
CAS#: 2110408-47-2
Chemical Formula: C20H33NO5
Exact Mass: 367.24
Molecular Weight: 367.486
Elemental Analysis: C, 65.37; H, 9.05; N, 3.81; O, 21.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: TTT20171; TTT-20171; TTT 20171;

IUPAC/Chemical Name: 4-hydroxy-5,6-dimethoxy-3-tridecanoylpyridin-2(1H)-one

InChi Key: CZKPAGLXQOQNEI-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H33NO5/c1-4-5-6-7-8-9-10-11-12-13-14-15(22)16-17(23)18(25-2)20(26-3)21-19(16)24/h4-14H2,1-3H3,(H2,21,23,24)

SMILES Code: COC1=C(OC)NC(C(C(CCCCCCCCCCCC)=O)=C1O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Mitochondrial complex II (CII) is an emerging target for numerous human diseases.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 367.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang H, Huwaimel B, Verma K, Miller J, Germain TM, Kinarivala N, Pappas D,
Brookes PS, Trippier PC. Synthesis and Antineoplastic Evaluation of Mitochondrial
Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5.
ChemMedChem. 2017 Jul 6;12(13):1033-1044. doi: 10.1002/cmdc.201700196. Epub 2017
Jun 12. PubMed PMID: 28523727; PubMed Central PMCID: PMC5557372.