Tuftsin
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MedKoo CAT#: 564826

CAS#: 9063-57-4

Description: Tuftsin is a self-immunomodulatory molecule produced by the spleen by enzymatic cleavage of a leukophilic gamma-globulin which stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.

Chemical Structure

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Tuftsin
CAS# 9063-57-4
Instruction

Theoretical Analysis

MedKoo Cat#: 564826
Name: Tuftsin
CAS#: 9063-57-4
Chemical Formula: C21H40N8O6
Exact Mass: 500.31
Molecular Weight: 500.600
Elemental Analysis: C, 50.39; H, 8.05; N, 22.38; O, 19.18

Price and Availability

Size Price Availability Quantity
5mg USD 240
10mg USD 375
25mg USD 565
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Synonym: Tuftsin

IUPAC/Chemical Name: Thr-Lys-Pro-Arg; L-Threonyl-L-lysyl-L-prolyl-L-arginine

InChi Key: IESDGNYHXIOKRW-YXMSTPNBSA-N

InChi Code: InChI=1S/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)/t12-,13+,14+,15+,16+/m1/s1

SMILES Code: N=C(N)NCCC[C@@H](C(O)=O)NC([C@H]1N(C([C@H](CCCCN)NC([C@H]([C@H](O)C)N)=O)=O)CCC1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 500.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Thompson KK, Nissen JC, Pretory A, Tsirka SE. Tuftsin Combines With Remyelinating Therapy and Improves Outcomes in Models of CNS Demyelinating Disease. Front Immunol. 2018 Nov 28;9:2784. doi: 10.3389/fimmu.2018.02784. eCollection 2018. PubMed PMID: 30555470; PubMed Central PMCID: PMC6283261.

2: Carneiro SP, Carvalho KV, de Oliveira Aguiar Soares RD, Carneiro CM, de Andrade MHG, Duarte RS, Dos Santos ODH. Functionalized rifampicin-loaded nanostructured lipid carriers enhance macrophages uptake and antimycobacterial activity. Colloids Surf B Biointerfaces. 2018 Dec 4;175:306-313. doi: 10.1016/j.colsurfb.2018.12.003. [Epub ahead of print] PubMed PMID: 30553206.

3: Paul R, Karthik S, Vimalraj P, Meenakshisundaram S, Kaliraj P. Cloning, large-scale production and characterization of fusion protein (P-TUFT-ALT-2) of Brugian abundant larval transcript-2 with tuftsin in Pichia pastoris. Prep Biochem Biotechnol. 2018 Oct 10:1-11. doi: 10.1080/10826068.2018.1514511. [Epub ahead of print] PubMed PMID: 30303452.

4: He XY, Liu BY, Xu C, Zhuo RX, Cheng SX. A multi-functional macrophage and tumor targeting gene delivery system for the regulation of macrophage polarity and reversal of cancer immunoresistance. Nanoscale. 2018 Aug 23;10(33):15578-15587. doi: 10.1039/c8nr05294h. PubMed PMID: 30090893.

5: Hu T, Qahtan ASA, Lei L, Lei Z, Zhao D, Nie H. Inhibition of HeLa cell growth by doxorubicin-loaded and tuftsin-conjugated arginate-PEG microparticles. Bioact Mater. 2017 May 6;3(1):48-54. doi: 10.1016/j.bioactmat.2017.04.007. eCollection 2018 Mar. PubMed PMID: 29744441; PubMed Central PMCID: PMC5935659.

6: Mo Z, Yu F, Han S, Yang S, Wu L, Li P, Jiao S. New peptide MY1340 revert the inhibition effect of VEGF on dendritic cells differentiation and maturation via blocking VEGF-NRP-1 axis and inhibit tumor growth in vivo. Int Immunopharmacol. 2018 Jul;60:132-140. doi: 10.1016/j.intimp.2018.04.025. Epub 2018 May 3. PubMed PMID: 29730556.

7: Segal Y, Blank M, Shoenfeld Y. Tuftsin phosphorylcholine-a novel compound harnessing helminths to fight autoimmunity. Immunol Res. 2018 Dec 15. doi: 10.1007/s12026-018-9051-2. [Epub ahead of print] Review. PubMed PMID: 30554380.