Miconidin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584742

CAS#: 34272-58-7

Description: Miconidin is found in Primula, a precursor to primin, and inhibits growth in Trypanosoma cruzi.

Chemical Structure

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Miconidin
CAS# 34272-58-7
Instruction

Theoretical Analysis

MedKoo Cat#: 584742
Name: Miconidin
CAS#: 34272-58-7
Chemical Formula: C12H18O3
Exact Mass: 210.13
Molecular Weight: 210.273
Elemental Analysis: C, 68.55; H, 8.63; O, 22.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Miconidin

IUPAC/Chemical Name: 1,4-Benzenediol, 2-methoxy-6-pentyl-

InChi Key: QYDCWUURASKCKV-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H18O3/c1-3-4-5-6-9-7-10(13)8-11(15-2)12(9)14/h7-8,13-14H,3-6H2,1-2H3

SMILES Code: OC1=C(CCCCC)C=C(O)C=C1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 210.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Paulsen E, Christensen LP, Andersen KE. Miconidin and miconidin methyl ether from Primula obconica Hance: new allergens in an old sensitizer. Contact Dermatitis. 2006 Oct;55(4):203-9. PubMed PMID: 16958917.

2: Sepúlveda-Boza S, Cassels BK. Plant metabolites active against Trypanosoma cruzi. Planta Med. 1996 Apr;62(2):98-105. Review. PubMed PMID: 8657759.

3: Krebs M, Christensen LP. 2-methoxy-6-pentyl-1,4-dihydroxybenzene (miconidin) from Primula obconica: a possible allergen? Contact Dermatitis. 1995 Aug;33(2):90-3. PubMed PMID: 8549150.

4: Christensen LP, Larsen E. Direct emission of the allergen primin from intact Primula obconica plants. Contact Dermatitis. 2000 Mar;42(3):149-53. PubMed PMID: 10727165.

5: Na P, Peng S, Zhang Y, Zhong Y. Composition of volatile oil of Primula obconica in Central China. Nat Prod Lett. 2002 Aug;16(4):249-53. PubMed PMID: 12168760.

6: Goijman SG, Turrens JF, Marini-Bettolo GB, Stoppani AO. [Inhibition of growth and macromolecular biosynthesis in Trypanosoma cruzi by natural products. Effects of miconidine and tingenone]. Medicina (B Aires). 1984;44(4):361-70. Spanish. PubMed PMID: 6399926.

7: Maioral MF, Stefanes NM, Bigolin Á, Zatelli GA, Philippus AC, de Barcellos Falkenberg M, Santos-Silva MC. MICONIDINE acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest New Drugs. 2018 Dec 19. doi: 10.1007/s10637-018-0694-6. [Epub ahead of print] PubMed PMID: 30569243.