M&B 2272

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530830

CAS#: 63951-44-0

Description: M&B 2272 is a drug/ therapeutic agent.

Chemical Structure

img
M&B 2272
CAS# 63951-44-0
Instruction

Theoretical Analysis

MedKoo Cat#: 530830
Name: M&B 2272
CAS#: 63951-44-0
Chemical Formula: C22H42I2N2
Exact Mass: 588.14
Molecular Weight: 588.401
Elemental Analysis: C, 44.91; H, 7.20; I, 43.14; N, 4.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: M&B 2272

IUPAC/Chemical Name: Ammonium, (4-(p-triethylammoniophenyl)butyl)triethyl-, diiodide

InChi Key: COIKZKVUCOJBTN-UHFFFAOYSA-L

InChi Code: InChI=1S/C22H42N2.2HI/c1-7-23(8-2,9-3)20-14-13-15-21-16-18-22(19-17-21)24(10-4,11-5)12-6;;/h16-19H,7-15,20H2,1-6H3;2*1H/q+2;;/p-2

SMILES Code: CC[N+](CC)(CCCCC1=CC=C([N+](CC)(CC)CC)C=C1)CC.[I-].[I-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 588.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Vallbracht M, Rehwaldt S, Klupp BG, Mettenleiter TC, Fuchs W. Functional Relevance of the N-Terminal Domain of Pseudorabies Virus Envelope Glycoprotein H and Its Interaction with Glycoprotein L. J Virol. 2017 Apr 13;91(9). pii: e00061-17. doi: 10.1128/JVI.00061-17. Print 2017 May 1. PubMed PMID: 28228592; PubMed Central PMCID: PMC5391448.

2: Inah BE, Ayi AA, Adhikary A. Crystal structure of a chloride-bridged copper(II) dimer: piperazine-1,4-dium bis-(di-μ-chlorido-bis[(4-carboxypyridine-2-carboxyl-ato-κ(2)N,O(2))chlorido-cupr ate(II)]. Acta Crystallogr E Crystallogr Commun. 2017 Jan 27;73(Pt 2):246-249. doi: 10.1107/S2056989017001013. eCollection 2017 Feb 1. PubMed PMID: 28217352; PubMed Central PMCID: PMC5290575.

3: Swann C, Crust L, Jackman P, Vella SA, Allen MS, Keegan R. Performing under pressure: Exploring the psychological state underlying clutch performance in sport. J Sports Sci. 2017 Dec;35(23):2272-2280. doi: 10.1080/02640414.2016.1265661. Epub 2016 Dec 16. PubMed PMID: 27981877.

4: Bargues MD, Malandrini JB, Artigas P, Soria CC, Velásquez JN, Carnevale S, Mateo L, Khoubbane M, Mas-Coma S. Human fascioliasis endemic areas in Argentina: multigene characterisation of the lymnaeid vectors and climatic-environmental assessment of the transmission pattern. Parasit Vectors. 2016 May 27;9(1):306. doi: 10.1186/s13071-016-1589-z. PubMed PMID: 27229862; PubMed Central PMCID: PMC4882814.

5: Nunes KP, Teixeira CE, Priviero FB, Toque HA, Webb RC. Beneficial effect of the soluble guanylyl cyclase stimulator BAY 41-2272 on impaired penile erection in db/db-/- type II diabetic and obese mice. J Pharmacol Exp Ther. 2015 May;353(2):330-9. doi: 10.1124/jpet.114.220970. Epub 2015 Mar 4. PubMed PMID: 25740897.

6: Schierloh P, Landoni V, Balboa L, Musella RM, Castagnino J, Moraña E, de Casado GC, Palmero D, Sasiain MC. Human pleural B-cells regulate IFN-γ production by local T-cells and NK cells in a Mycobacterium tuberculosis-induced delayed hypersensitivity reaction. Clin Sci (Lond). 2014 Sep;127(6):391-403. doi: 10.1042/CS20130769. PubMed PMID: 24689690.

7: Silva FH, Mónica FZ, Báu FR, Brugnerotto AF, Priviero FB, Toque HA, Antunes E. Superoxide anion production by NADPH oxidase plays a major role in erectile dysfunction in middle-aged rats: prevention by antioxidant therapy. J Sex Med. 2013 Apr;10(4):960-71. doi: 10.1111/jsm.12063. Epub 2013 Jan 24. PubMed PMID: 23347406.

8: Tkachuk AV, Mar A. Structure and physical properties of ternary rare-earth cobalt bismuth intermetallics (RE)12Co5Bi (RE = Y, Gd, Tb, Dy, Ho, Er, Tm). Inorg Chem. 2005 Apr 4;44(7):2272-81. PubMed PMID: 15792462.

9: Thomazzi SM, Moreira J, De Nucci G, Antunes E. Inhibitory effects on human eosinophil chemotaxis in vitro by BAY 41-2272, an activator of nitric oxide-independent site of soluble guanylate cyclase. Biochem Pharmacol. 2005 Mar 15;69(6):875-82. PubMed PMID: 15748699.

10: Keating J, Pater P, Lolohea S, Wickremesekera K. The epidemiology of colorectal cancer: what can we learn from the New Zealand Cancer Registry? N Z Med J. 2003 May 16;116(1174):U437. PubMed PMID: 12766783.

11: Cellek S. The Rho-kinase inhibitor Y-27632 and the soluble guanylyl cyclase activator BAY41-2272 relax rabbit vaginal wall and clitoral corpus cavernosum. Br J Pharmacol. 2003 Jan;138(2):287-90. PubMed PMID: 12540518; PubMed Central PMCID: PMC1573674.

12: Opher M, Morales GJ, Leboeuf JN. Krook collisional models of the kinetic susceptibility of plasmas. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Jul;66(1 Pt 2):016407. Epub 2002 Jul 29. PubMed PMID: 12241490.

13: de Larrañaga GF, Harris N, Pierangeli SS, Alonso BS, Schroder T, Fainboim H. [Low prevalence of autoimmune antiphospholipid antibodies in hepatic diseases]. Medicina (B Aires). 2000;60(6):919-22. Spanish. PubMed PMID: 11436702.

14: van den Hemel-Grooten HN, Koohmaraie M, Yen JT, Arbona JR, Rathmacher JA, Nissen SL, Fiorotto ML, Garssen GJ, Verstegen MW. Comparison between 3-methylhistidine production and proteinase activity as measures of skeletal muscle breakdown in protein-deficient growing barrows. J Anim Sci. 1995 Aug;73(8):2272-81. PubMed PMID: 8567463.

15: Nguyen BT, El Sayed YM, Sadée W. Interaction among the distinct effects of adenine and guanine depletion in mouse lymphoma cells. Cancer Res. 1984 Jun;44(6):2272-7. PubMed PMID: 6722768.