Lyoniol-A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530291

CAS#: 31136-61-5

Description: Lyoniol-A is a toxic component from poisonous tree in Japan(Lyonia ovalifolia var. elliptica).

Chemical Structure

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Lyoniol-A
CAS# 31136-61-5
Instruction

Theoretical Analysis

MedKoo Cat#: 530291
Name: Lyoniol-A
CAS#: 31136-61-5
Chemical Formula: C22H34O7
Exact Mass: 410.23
Molecular Weight: 410.507
Elemental Analysis: C, 64.37; H, 8.35; O, 27.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Lyoniol-A

IUPAC/Chemical Name: 7,9a-Methano-9aH-cyclopenta(b)heptalene-4,8,10,11,11a(1H)-pentol, 2,3-epoxydodecahydro-1,1,4,8-tetramethyl-, 11-acetate, (2R,3S,3as,4R,4ar,7R,8R,9ar,10S,11R,11aR)-

InChi Key: ASDPUXKPNOGLSZ-CRRNJOFASA-N

InChi Code: InChI=1S/C22H34O7/c1-10(23)28-17-15(24)21-8-11(19(4,25)9-21)6-7-12(21)20(5,26)14-13-16(29-13)18(2,3)22(14,17)27/h11-17,24-27H,6-9H2,1-5H3/t11-,12+,13+,14+,15-,16+,17-,19-,20-,21-,22+/m1/s1

SMILES Code: O[C@@]1(C)[C@@]2([H])[C@](C(C)(C)[C@]3([H])[C@@]2([H])O3)(O)[C@H](OC(C)=O)[C@@H](O)[C@]45C[C@](O)(C)[C@](C5)([H])CC[C@@]14[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang HP, Wang LQ, Qin GW. Grayanane diterpenoids from the leaves of Craiobiodendron yunnanense. Bioorg Med Chem. 2005 Sep 1;13(17):5289-98. PubMed PMID: 15990321.

2: Ono H, Fukuda H, Kudo Y. Excitation by lyoniol-A of vagal afferent nerves and the reflex autonomic and somatic actions in rats. J Pharmacobiodyn. 1981 Dec;4(12):940-6. PubMed PMID: 7341750.

3: Sakakibara J, Ikai K, Yasue M. [Studies on the constituents of Lyonia ovalifolia Drude var. elliptica Hand.-Mazz. XVIII. Structure of diterpenoid, lyoniol-D and correlation of lyoniol-A(lyoniatoxin) with grayanotoxin-I]. Yakugaku Zasshi. 1974 Dec;94(12):1534-40. Japanese. PubMed PMID: 4476755.

4: Fukuda H, Kudo Y, Ono H. Excitation of rat muscle spindle afferents by lyoniol-A. Eur J Pharmacol. 1974 May;26(2):136-42. PubMed PMID: 4851955.

5: Fukuda H, Kudo Y, Ono H, Yasue M, Sakakibara J. Structure-activity relationship of lyoniol-A and related compounds in association with the excitatory effect on muscle spindle afferents. Chem Pharm Bull (Tokyo). 1974 Apr;22(4):884-8. PubMed PMID: 4418756.

6: Fukuda H, Watanabe K, Ito T. Effect of lyoniol-A on decerebrate rigidity and electroencephalogram in rats. Jpn J Pharmacol. 1972 Aug;22(4):457-65. PubMed PMID: 4118933.

7: Kato T, Sakakibara J, Yasue M. [Studies on the constituents of Lyonia ovalifolia Drude var. elliptica Hand.-Mazz. XIV. Structure of diterpenoid, lyoniol-A (lyoniatoxin). (3)]. Yakugaku Zasshi. 1971 Nov;91(11):1194-9. Japanese. PubMed PMID: 5169125.

8: Yasue M, Sakakibara J, Kato T. [Studies on the constituents of Lyonia ovalifolia Drude var. elliptica Hand-Mazz. 13. Structure of diterpenoid, lyoniol-A(lyoniatoxin). (2)]. Yakugaku Zasshi. 1971 Mar;91(3):358-62. Japanese. PubMed PMID: 5105074.

9: Yasue M, Kato T, Sakakibara J. [Studies on the constituents of Lyonia ovalifolia Drude var. elliptica Hand.-Mazz. IX. Structure of lyoniol-A(lyoniatoxin), the main component of the toxic principles. (1)]. Yakugaku Zasshi. 1970 Jul;90(7):893-8. Japanese. PubMed PMID: 4194864.

10: Fukuda H, Watanabe K, Ito T. A comparison of the effects of lyoniol-A, strychnine and pentylenetetrazol on the evoked electromyogram in young chickens. Jpn J Pharmacol. 1969 Sep;19(3):394-400. PubMed PMID: 5307472.

11: Fukuda H, Watanabe K, Ito T. [Pharmacology of Lyoniol-A, an amyostatic component from Lyonia ovalifolia var. elliptica (ericaceae). I]. Yakugaku Zasshi. 1969 Mar;89(3):382-8. Japanese. PubMed PMID: 5815799.