Midesteine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584732

CAS#: 94149-41-4

Description: Midesteine is a cyclic thiolic neutrophil elastase inhibitor.

Chemical Structure

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Midesteine
CAS# 94149-41-4
Instruction

Theoretical Analysis

MedKoo Cat#: 584732
Name: Midesteine
CAS#: 94149-41-4
Chemical Formula: C12H13NO3S3
Exact Mass: 315.01
Molecular Weight: 315.420
Elemental Analysis: C, 45.70; H, 4.15; N, 4.44; O, 15.22; S, 30.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Midesteine; MR 889; MR889; MR-889.

IUPAC/Chemical Name: 2-Thiophenecarbothioic acid, S-(1-methyl-2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl) ester

InChi Key: RZSPDIRWSJHFTB-MQWKRIRWSA-N

InChi Code: InChI=1S/C12H13NO3S3/c1-7(16-12(17)9-3-2-5-18-9)10(14)13-8-4-6-19-11(8)15/h2-3,5,7-8H,4,6H2,1H3,(H,13,14)/t7?,8-/m0/s1

SMILES Code: S=C(C1=CC=CS1)OC(C)C(N[C@@H](CCS2)C2=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 315.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Luisetti M, Piccioni PD, Donnini M, Peona V, Pozzi E, Grassi C. Studies of MR 889, a new synthetic proteinase inhibitor. Biochem Biophys Res Commun. 1989 Dec 15;165(2):568-73. PubMed PMID: 2597145.

2: Luisetti M, Piccioni PD, Donnini M, Alesina R, Donnetta AM, Peona V. On the activity of MR 889, a new synthetic proteinase inhibitor. Ann N Y Acad Sci. 1991;624:343-4. PubMed PMID: 1712157.

3: Gentili P, Pelloso R, La Rosa C, Galzigna L, Lucarelli C. Absorption, distribution, metabolism and excretion of 2-[2-thiophenecarboxythio]-N-[dihydro-2-(3H)-thiophenone-3-yl]-propiona mide in the rat. Arzneimittelforschung. 1990 Nov;40(11):1214-7. PubMed PMID: 2085332.

4: Luisetti M, Sturani C, Sella D, Madonini E, Galavotti V, Bruno G, Peona V, Kucich U, Dagnino G, Rosenbloom J, Starcher B, Grassi C. MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial. Eur Respir J. 1996 Jul;9(7):1482-6. PubMed PMID: 8836663.

5: Ohbayashi H. Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. Review. PubMed PMID: 12084007.

6: Baici A, Pelloso R, Hörler D. The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound. Biochem Pharmacol. 1990 Mar 1;39(5):919-24. PubMed PMID: 2310417.

7: Moretti M, Gorrini M, Donnetta AM, Baldini EV, Venturini R, Marchioni CF, Iadarola P, Luisetti M. Effects of MR889, a cyclic thiolic neutrophil elastase inhibitor, on rheologic properties of mucus. Life Sci. 1994;54(7):463-9. PubMed PMID: 8309349.