3-Deoxysappanchalcone | CAS# 112408-67-0 | Anti-Inflammatory Agent

3-Deoxysappanchalcone
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564526

CAS#: 112408-67-0

Description: 3-Deoxysappanchalcone is a natural anti-inflammatory agent, inducing heme oxygenase-1 via activation of the AKT/mTOR pathway in murine macrophages.

Chemical Structure

3-Deoxysappanchalcone

CAS# 112408-67-0

Instruction

Theoretical Analysis

MedKoo Cat#: 564526
Name: 3-Deoxysappanchalcone
CAS#: 112408-67-0
Chemical Formula: C16H14O4
Exact Mass: 270.09
Molecular Weight: 270.280
Elemental Analysis: C, 71.10; H, 5.22; O, 23.68

Price and Availability

Size	Price	Availability
5mg	USD 550	2 Weeks
10mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: 2'-O-Methylisoliquiritigenin; 3-Deoxysappanchalcone

IUPAC/Chemical Name: (E)-1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

InChi Key: PACBGANPVNHGNP-RUDMXATFSA-N

InChi Code: InChI=1S/C16H14O4/c1-20-16-10-13(18)7-8-14(16)15(19)9-4-11-2-5-12(17)6-3-11/h2-10,17-18H,1H3/b9-4+

SMILES Code: O=C(C1=CC=C(O)C=C1OC)/C=C/C2=CC=C(O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 270.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Escobar-Ramos A, Lobato-García CE, Zamilpa A, Gómez-Rivera A, Tortoriello J, González-Cortazar M. Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity. Molecules. 2017 Aug 24;22(9). pii: E1405. doi: 10.3390/molecules22091405. PubMed PMID: 28837100; PubMed Central PMCID: PMC6151460.

2: Seo H, Kim S, Mahmud HA, Islam MI, Nam KW, Lee BE, Lee H, Cho ML, Shin HM, Song HY. In vitro Antitubercular Activity of 3-Deoxysappanchalcone Isolated From the Heartwood of Caesalpinia sappan Linn. Phytother Res. 2017 Oct;31(10):1600-1606. doi: 10.1002/ptr.5890. Epub 2017 Aug 17. PubMed PMID: 28816372.

3: Kim YE, Choi HC, Lee IC, Yuk DY, Lee H, Choi BY. 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling. Biomol Ther (Seoul). 2016 Nov 1;24(6):572-580. doi: 10.4062/biomolther.2016.183. PubMed PMID: 27795451; PubMed Central PMCID: PMC5098535.

4: Kim JH, Choo YY, Tae N, Min BS, Lee JH. The anti-inflammatory effect of 3-deoxysappanchalcone is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages. Int Immunopharmacol. 2014 Oct;22(2):420-6. doi: 10.1016/j.intimp.2014.07.025. Epub 2014 Aug 1. PubMed PMID: 25091623.

5: Yang F, Zhou WL, Liu AL, Qin HL, Lee SM, Wang YT, Du GH. The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation. Planta Med. 2012 Jun;78(10):968-73. doi: 10.1055/s-0031-1298620. Epub 2012 May 30. PubMed PMID: 22648377.

6: Youn UJ, Nam KW, Kim HS, Choi G, Jeong WS, Lee MY, Chae S. 3-Deoxysappanchalcone inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in human keratinocytes through activated protein-1 inhibition and nuclear factor-kappa B DNA binding activity. Biol Pharm Bull. 2011;34(6):890-3. PubMed PMID: 21628889.

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