ZK187638

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564435

CAS#: 397298-63-4

Description: ZK187638 is a non-competitive AMPA receptor antagonist.

Chemical Structure

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ZK187638
CAS# 397298-63-4
Instruction

Theoretical Analysis

MedKoo Cat#: 564435
Name: ZK187638
CAS#: 397298-63-4
Chemical Formula: C20H17N3O2
Exact Mass: 331.13
Molecular Weight: 331.380
Elemental Analysis: C, 72.49; H, 5.17; N, 12.68; O, 9.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ZK-187638; ZK 187638; ZK187638

IUPAC/Chemical Name: 2,3-Dimethyl-6-phenyl-12H-[1,3]dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine

InChi Key: ZFQASTCWCGRURV-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H17N3O2/c1-12-13(2)23-19(21-12)9-15-8-17-18(25-11-24-17)10-16(15)20(22-23)14-6-4-3-5-7-14/h3-8,10H,9,11H2,1-2H3

SMILES Code: CC1=C(C)N=C2N1N=C(C3=CC=CC=C3)C4=CC(OCO5)=C5C=C4C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 331.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Elger B, Gieseler M, Schmuecker O, Schumann I, Seltz A, Huth A. Extended therapeutic time window after focal cerebral ischemia by non-competitive inhibition of AMPA receptors. Brain Res. 2006 Apr 26;1085(1):189-94. Epub 2006 Apr 3. PubMed PMID: 16580649.

2: Elger B, Huth A, Neuhaus R, Ottow E, Schneider H, Seilheimer B, Turski L. Novel alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration. J Med Chem. 2005 Jul 14;48(14):4618-27. PubMed PMID: 15999999.

3: Tortarolo M, Grignaschi G, Calvaresi N, Zennaro E, Spaltro G, Colovic M, Fracasso C, Guiso G, Elger B, Schneider H, Seilheimer B, Caccia S, Bendotti C. Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease. J Neurosci Res. 2006 Jan;83(1):134-46. PubMed PMID: 16323214.

4: Elger B, Schneider M, Winter E, Carvelli L, Bonomi M, Fracasso C, Guiso G, Colovic M, Caccia S, Mennini T. Optimized synthesis of AMPA receptor antagonist ZK 187638 and neurobehavioral activity in a mouse model of neuronal ceroid lipofuscinosis. ChemMedChem. 2006 Oct;1(10):1142-8. PubMed PMID: 16972289.