ADP-2341

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564271

CAS#: 2149619-47-4

Description: ADP-2341 is a soluble analog of FiVe1. ADP-2341 displayed enhanced solubility with respect to FiVe1 and retained potent and selective cellular activity in proliferation assay.

Chemical Structure

img
ADP-2341
CAS# 2149619-47-4
Instruction

Theoretical Analysis

MedKoo Cat#: 564271
Name: ADP-2341
CAS#: 2149619-47-4
Chemical Formula: C24H29Cl2N5O3
Exact Mass: 505.16
Molecular Weight: 506.430
Elemental Analysis: C, 56.92; H, 5.77; Cl, 14.00; N, 13.83; O, 9.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ADP2341; ADP 2341; ADP-2341

IUPAC/Chemical Name: 2-(2-(2-(3-chloro-5-(4-(8-chlorocinnolin-4-yl)piperazin-1-yl)phenoxy)ethoxy)ethoxy)ethan-1-amine

InChi Key: MSZAROLOQGWZRX-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H29Cl2N5O3/c25-18-14-19(16-20(15-18)34-13-12-33-11-10-32-9-4-27)30-5-7-31(8-6-30)23-17-28-29-24-21(23)2-1-3-22(24)26/h1-3,14-17H,4-13,27H2

SMILES Code: NCCOCCOCCOC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC(Cl)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info: Expression of the transcription factor FOXC2 is induced and necessary for successful epithelial-​mesenchymal transition, a developmental program that when activated in cancer endows cells with metastatic potential and the properties of stem cells. As such, identifying agents that inhibit the growth of FOXC2-​transformed cells represents an attractive approach to inhibit chemotherapy resistance and metastatic dissemination.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 506.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Bollong MJ, Pietilä M, Pearson AD, et al. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017;114(46):E9903-E9912. doi:10.1073/pnas.1716009114