Heliantriol B2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528033

CAS#: 61229-18-3

Description: Heliantriol B2 Antineoplastic Agents, Phytogenic; from Chuquiraga erinacea.

Chemical Structure

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Heliantriol B2
CAS# 61229-18-3
Instruction

Theoretical Analysis

MedKoo Cat#: 528033
Name: Heliantriol B2
CAS#: 61229-18-3
Chemical Formula: C30H50O3
Exact Mass: 458.38
Molecular Weight: 458.727
Elemental Analysis: C, 78.55; H, 10.99; O, 10.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Heliantriol B2

IUPAC/Chemical Name: Lup-20(29)-ene-3,16,28-triol

InChi Key: TWKNDDJHVQUEJF-FQJNEUTDSA-N

InChi Code: InChI=1S/C30H50O3/c1-18(2)19-10-15-30(17-31)24(33)16-29(7)20(25(19)30)8-9-22-27(5)13-12-23(32)26(3,4)21(27)11-14-28(22,29)6/h19-25,31-33H,1,8-17H2,2-7H3/t19-,20+,21-,22+,23?,24?,25+,27-,28+,29+,30-/m0/s1

SMILES Code: CC1(C)C(O)CC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C)=C)CC[C@@](CO)5C(O)C[C@](C)4[C@@](C)3CC[C@@]12[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 458.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gurovic MS, Lanza AM, Adánez Mdel C, Omaña MC, Gómez IG, Murray AP, López PS. Cytotoxic effects induced by combination of heliantriol B2 and dequalinium against human leukemic cell lines. Phytother Res. 2011 Apr;25(4):603-10. doi: 10.1002/ptr.3310. Epub 2010 Oct 26. PubMed PMID: 20981868.

2: Gurovic MS, Castro MJ, Richmond V, Faraoni MB, Maier MS, Murray AP. Triterpenoids with acetylcholinesterase inhibition from Chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae). Planta Med. 2010 Apr;76(6):607-10. doi: 10.1055/s-0029-1240582. Epub 2009 Nov 16. PubMed PMID: 19918718.

3: Ukiya M, Akihisa T, Tokuda H, Suzuki H, Mukainaka T, Ichiishi E, Yasukawa K, Kasahara Y, Nishino H. Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers. Cancer Lett. 2002 Mar 8;177(1):7-12. PubMed PMID: 11809525.

4: Yasukawa K, Akihisa T, Oinuma H, Kasahara Y, Kimura Y, Yamanouchi S, Kumaki K, Tamura T, Takido M. Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Biol Pharm Bull. 1996 Oct;19(10):1329-31. PubMed PMID: 8913506.