Dipyridamole tripiperidine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 593099

CAS#: 16982-40-4

Description: Dipyridamole tripiperidine is a biochemical.

Chemical Structure

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Dipyridamole tripiperidine
CAS# 16982-40-4
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 593099
Name: Dipyridamole tripiperidine
CAS#: 16982-40-4
Chemical Formula: C25H40N8O2
Exact Mass: 484.33
Molecular Weight: 484.649
Elemental Analysis: C, 61.96; H, 8.32; N, 23.12; O, 6.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Dipyridamole tripiperidine

IUPAC/Chemical Name: Ethanol, 2,2'-((4,6,8-tripiperidinopyrimido(5,4-d)pyrimidin-2-yl)imino)di- (7ci,8ci)

InChi Key: QYMDDAUYVDAXDI-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H40N8O2/c34-18-16-33(17-19-35)25-27-21-20(23(29-25)31-12-6-2-7-13-31)26-24(32-14-8-3-9-15-32)28-22(21)30-10-4-1-5-11-30/h34-35H,1-19H2

SMILES Code: OCCN(CCO)C1=NC(N2CCCCC2)=C(N=C(N3CCCCC3)N=C4N5CCCCC5)C4=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Dipyridamole tripiperidine is a biochemical.
In vitro activity: A MTT assay is used to evaluate the proliferation of cancer cells. The addition of dipyridamole (0–20 µM) increased the proliferation of U937 cells, parent HCT-8 cells and the CD133+/CD44+ stem-like subpopulation of HCT-8 cells in a dose-dependent manner (Fig. 1A). Reference: Oncol Lett. 2021 Apr;21(4):251. https://pubmed.ncbi.nlm.nih.gov/33664815/
In vivo activity: Dipyridamole significantly ameliorated doxorubicin-induced cardiotoxicity in rats, as suggested by the significantly decreased inflammatory mediators TNF-α and IL-6 (Figures 1 and 2). Cardiac tissue level of the oxidative marker MDA significantly decreased (Figure 3) and also significantly increased in TAC (Figure 4) with the dipyridamole group compared to the doxorubicin-only group. Additionally, dipyridamole significantly attenuated doxorubicin-induced apoptosis, reflected by lower cardiac caspase-3 level (Figure 5) and significant elevation in Bcl-2 compared to the doxorubicin-only group (Figure 6). Reference: J Med Life. 2022 Sep;15(9):1184-1190. https://pubmed.ncbi.nlm.nih.gov/36415530/

Preparing Stock Solutions

The following data is based on the product molecular weight 484.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Abdelghany L, El-Mahdy N, Kawabata T, Goto S, Li TS. Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation. Oncol Lett. 2021 Apr;21(4):251. doi: 10.3892/ol.2021.12512. Epub 2021 Feb 3. PMID: 33664815; PMCID: PMC7882894. 2. Wang JD, Wang YY, Lin SY, Chang CY, Li JR, Huang SW, Chen WY, Liao SL, Chen CJ. Exosomal HMGB1 Promoted Cancer Malignancy. Cancers (Basel). 2021 Feb 19;13(4):877. doi: 10.3390/cancers13040877. PMID: 33669632; PMCID: PMC7921955. 3. Alyasiry E, Janabi A, Hadi N. Dipyridamole ameliorates doxorubicin-induced cardiotoxicity. J Med Life. 2022 Sep;15(9):1184-1190. doi: 10.25122/jml-2021-0199. PMID: 36415530; PMCID: PMC9635225. 4. Esmaeili S, Azizian S, Shahmoradi B, Moradi S, Shahlaei M, Khodarahmi R. Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies. Bioorg Chem. 2019 Jul;88:102972. doi: 10.1016/j.bioorg.2019.102972. Epub 2019 May 6. PMID: 31078769.
In vitro protocol: 1. Abdelghany L, El-Mahdy N, Kawabata T, Goto S, Li TS. Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation. Oncol Lett. 2021 Apr;21(4):251. doi: 10.3892/ol.2021.12512. Epub 2021 Feb 3. PMID: 33664815; PMCID: PMC7882894. 2. Wang JD, Wang YY, Lin SY, Chang CY, Li JR, Huang SW, Chen WY, Liao SL, Chen CJ. Exosomal HMGB1 Promoted Cancer Malignancy. Cancers (Basel). 2021 Feb 19;13(4):877. doi: 10.3390/cancers13040877. PMID: 33669632; PMCID: PMC7921955.
In vivo protocol: 1. Alyasiry E, Janabi A, Hadi N. Dipyridamole ameliorates doxorubicin-induced cardiotoxicity. J Med Life. 2022 Sep;15(9):1184-1190. doi: 10.25122/jml-2021-0199. PMID: 36415530; PMCID: PMC9635225. 2. Esmaeili S, Azizian S, Shahmoradi B, Moradi S, Shahlaei M, Khodarahmi R. Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies. Bioorg Chem. 2019 Jul;88:102972. doi: 10.1016/j.bioorg.2019.102972. Epub 2019 May 6. PMID: 31078769.

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