Dicamba
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MedKoo CAT#: 558619

CAS#: 1918-00-9

Description: Dicamba is a chlorinated organic herbicide. It is used to selectively control broadleaf weeds.

Chemical Structure

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Dicamba
CAS# 1918-00-9
Instruction

Theoretical Analysis

MedKoo Cat#: 558619
Name: Dicamba
CAS#: 1918-00-9
Chemical Formula: C8H6Cl2O3
Exact Mass: 219.97
Molecular Weight: 221.030
Elemental Analysis: C, 43.47; H, 2.74; Cl, 32.08; O, 21.71

Price and Availability

Size Price Availability Quantity
1g USD 250 2 weeks
5g USD 550 2 Weeks
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Synonym: Dicamba; Banlen; Banvel; Dianat; Mediben;

IUPAC/Chemical Name: Benzoic acid, 3,6-dichloro-2-methoxy-

InChi Key: IWEDIXLBFLAXBO-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H6Cl2O3/c1-13-7-5(10)3-2-4(9)6(7)8(11)12/h2-3H,1H3,(H,11,12)

SMILES Code: O=C(O)C1=C(Cl)C=CC(Cl)=C1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 221.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jugulam M, Ziauddin A, So KK, Chen S, Hall JC. Transfer of Dicamba Tolerance from Sinapis arvensis to Brassica napus via Embryo Rescue and Recurrent Backcross Breeding. PLoS One. 2015 Nov 4;10(11):e0141418. doi: 10.1371/journal.pone.0141418. eCollection 2015. PubMed PMID: 26536372; PubMed Central PMCID: PMC4633294.

2: Ruiz de Arcaute C, Soloneski S, Larramendy ML. Evaluation of the genotoxicity of a herbicide formulation containing 3,6-dichloro-2-metoxybenzoic acid (dicamba) in circulating blood cells of the tropical fish Cnesterodon decemmaculatus. Mutat Res Genet Toxicol Environ Mutagen. 2014 Oct;773:1-8. doi: 10.1016/j.mrgentox.2014.08.001. Epub 2014 Aug 19. PubMed PMID: 25308699.

3: Moon JM, Chun BJ. Clinical characteristics of patients after dicamba herbicide ingestion. Clin Toxicol (Phila). 2014 Jan;52(1):48-53. doi: 10.3109/15563650.2013.870342. Epub 2013 Dec 18. PubMed PMID: 24351123.

4: Zhu L, Li W, Zha J, Wang Z. Dicamba affects sex steroid hormone level and mRNA expression of related genes in adult rare minnow (Gobiocypris rarus) at environmentally relevant concentrations. Environ Toxicol. 2015 May-Jun;30(6):693-703. doi: 10.1002/tox.21947. Epub 2014 Jan 13. PubMed PMID: 24420721.

5: Olszyk D, Pfleeger T, Lee EH, Plocher M. Glyphosate and dicamba herbicide tank mixture effects on native plant and non-genetically engineered soybean seedlings. Ecotoxicology. 2015 Jul;24(5):1014-27. doi: 10.1007/s10646-015-1442-8. Epub 2015 Mar 28. PubMed PMID: 25821135.

6: Reynoso MS, Alvarez CM, De la Cruz L, Escoto MD, Sánchez JJ. Evaluation of the genotoxic activity of dicamba and atrazine herbicides in several Mexican and South American varieties of sweetcorn (Zea mays L.). Genet Mol Res. 2015 Dec 11;14(4):16585-93. doi: 10.4238/2015.December.11.5. PubMed PMID: 26681004.

7: Bohnenblust E, Egan JF, Mortensen D, Tooker J. Direct and indirect effects of the synthetic-auxin herbicide dicamba on two lepidopteran species. Environ Entomol. 2013 Jun;42(3):586-94. doi: 10.1603/EN13021. PubMed PMID: 23726069.

8: Bohnenblust EW, Vaudo AD, Egan JF, Mortensen DA, Tooker JF. Effects of the herbicide dicamba on nontarget plants and pollinator visitation. Environ Toxicol Chem. 2016 Jan;35(1):144-51. doi: 10.1002/etc.3169. Epub 2015 Nov 24. PubMed PMID: 26184786.

9: Osborne PP, Xu Z, Swanson KD, Walker T, Farmer DK. Dicamba and 2,4-D residues following applicator cleanout: A potential point source to the environment and worker exposure. J Air Waste Manag Assoc. 2015 Sep;65(9):1153-8. doi: 10.1080/10962247.2015.1072593. PubMed PMID: 26199008.

10: Chávez-Moreno C, Ferrer L, Hinojosa-Reyes L, Hernández-Ramírez A, Cerdà V, Guzmán-Mar J. On-line monitoring of the photocatalytic degradation of 2,4-D and dicamba using a solid-phase extraction-multisyringe flow injection system. J Environ Manage. 2013 Nov 15;129:377-83. doi: 10.1016/j.jenvman.2013.08.007. Epub 2013 Aug 28. PubMed PMID: 23994580.

11: Yao L, Yu LL, Zhang JJ, Xie XT, Tao Q, Yan X, Hong Q, Qiu JG, He J, Ding DR. A Tetrahydrofolate-Dependent Methyltransferase Catalyzing the Demethylation of Dicamba in Sphingomonas sp. Strain Ndbn-20. Appl Environ Microbiol. 2016 Aug 30;82(18):5621-30. doi: 10.1128/AEM.01201-16. Print 2016 Sep 15. PubMed PMID: 27422839; PubMed Central PMCID: PMC5007784.

12: Brkić D, Szakonyne-Pasics I, Gašić S, Teodorović I, Rašković B, Brkić N, Nešković N. Subacute and subchronic toxicity of Avalon(®) mixture (bentazone+dicamba) to rats. Environ Toxicol Pharmacol. 2015 May;39(3):1057-66. doi: 10.1016/j.etap.2015.03.004. Epub 2015 Mar 14. PubMed PMID: 25863332.

13: Egan JF, Mortensen DA. Quantifying vapor drift of dicamba herbicides applied to soybean. Environ Toxicol Chem. 2012 May;31(5):1023-31. doi: 10.1002/etc.1778. Epub 2012 Mar 13. PubMed PMID: 22362509.

14: Kurenbach B, Marjoshi D, Amábile-Cuevas CF, Ferguson GC, Godsoe W, Gibson P, Heinemann JA. Sublethal exposure to commercial formulations of the herbicides dicamba, 2,4-dichlorophenoxyacetic acid, and glyphosate cause changes in antibiotic susceptibility in Escherichia coli and Salmonella enterica serovar Typhimurium. MBio. 2015 Mar 24;6(2). pii: e00009-15. doi: 10.1128/mBio.00009-15. PubMed PMID: 25805724; PubMed Central PMCID: PMC4453521.

15: Ghoshdastidar AJ, Tong AZ. Treatment of 2,4-D, mecoprop, and dicamba using membrane bioreactor technology. Environ Sci Pollut Res Int. 2013 Aug;20(8):5188-97. doi: 10.1007/s11356-013-1498-z. Epub 2013 Jan 30. PubMed PMID: 23361178.

16: Waltz E. Monsanto adds dicamba to its cache to counter weed threat. Nat Biotechnol. 2015 Apr;33(4):328. doi: 10.1038/nbt0415-328. PubMed PMID: 25850047.

17: Freydier L, Lundgren JG. Unintended effects of the herbicides 2,4-D and dicamba on lady beetles. Ecotoxicology. 2016 Aug;25(6):1270-7. doi: 10.1007/s10646-016-1680-4. Epub 2016 Jun 9. PubMed PMID: 27282375.

18: Wang C, Glenn KC, Kessenich C, Bell E, Burzio LA, Koch MS, Li B, Silvanovich A. Safety assessment of dicamba mono-oxygenases that confer dicamba tolerance to various crops. Regul Toxicol Pharmacol. 2016 Nov;81:171-182. doi: 10.1016/j.yrtph.2016.08.014. Epub 2016 Aug 27. PubMed PMID: 27575686.

19: Kimura O, Tsukagoshi K, Hayasaka M, Endo T. Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells. Arch Toxicol. 2012 Jan;86(1):55-61. doi: 10.1007/s00204-011-0734-x. Epub 2011 Jul 16. PubMed PMID: 21766207.

20: Kumar V, Jha P. Differences in Germination, Growth, and Fecundity Characteristics of Dicamba-Fluroxypyr-Resistant and Susceptible Kochia scoparia. PLoS One. 2016 Aug 18;11(8):e0161533. doi: 10.1371/journal.pone.0161533. eCollection 2016. PubMed PMID: 27537419; PubMed Central PMCID: PMC4990274.