Dicyclohexyl phthalate
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MedKoo CAT#: 558592

CAS#: 84-61-7

Description: Dicyclohexyl phthalate is a white granular solid. It is used as a plasticizer to modify the properties of synthetic resins, in alkyd resins and cellulose nitrate to increase their stability to light and weathering, and to improve the chemical and physical properties of plastics by preventing creep.

Chemical Structure

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Dicyclohexyl phthalate
CAS# 84-61-7
Instruction

Theoretical Analysis

MedKoo Cat#: 558592
Name: Dicyclohexyl phthalate
CAS#: 84-61-7
Chemical Formula: C20H26O4
Exact Mass: 330.18
Molecular Weight: 330.420
Elemental Analysis: C, 72.70; H, 7.93; O, 19.37

Price and Availability

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25g USD 350 2 weeks
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Synonym: Dicyclohexyl phthalate; Diclohexyl 1,2-benzenedicarboxylate; Phthalic acid, dicyclohexyl ester; 1,2-Benzenedicarboxylic acid, dicyclohexyl ester;

IUPAC/Chemical Name: 1,2-Benzenedicarboxylic acid, 1,2-dicyclohexyl ester

InChi Key: VOWAEIGWURALJQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H26O4/c21-19(23-15-9-3-1-4-10-15)17-13-7-8-14-18(17)20(22)24-16-11-5-2-6-12-16/h7-8,13-16H,1-6,9-12H2

SMILES Code: O=C(C1=CC=CC=C1C(OC2CCCCC2)=O)OC3CCCCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 330.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Aydoğan Ahbab M, Barlas N. Influence of in utero di-n-hexyl phthalate and dicyclohexyl phthalate on fetal testicular development in rats. Toxicol Lett. 2015 Mar 4;233(2):125-37. doi: 10.1016/j.toxlet.2015.01.015. Epub 2015 Jan 28. PubMed PMID: 25637754.

2: Aydoğan Ahbab M, Barlas N. Developmental effects of prenatal di-n-hexyl phthalate and dicyclohexyl phthalate exposure on reproductive tract of male rats: Postnatal outcomes. Food Chem Toxicol. 2013 Jan;51:123-36. doi: 10.1016/j.fct.2012.09.010. Epub 2012 Sep 25. PubMed PMID: 23022015.

3: Ahbab MA, Ündeğer Ü, Barlas N, Başaran N. In utero exposure to dicyclohexyl and di-n-hexyl phthalate possess genotoxic effects on testicular cells of male rats after birth in the comet and TUNEL assays. Hum Exp Toxicol. 2014 Mar;33(3):230-9. doi: 10.1177/0960327113494903. Epub 2013 Jul 8. PubMed PMID: 23836838.

4: Li X, Chen X, Hu G, Li L, Su H, Wang Y, Chen D, Zhu Q, Li C, Li J, Wang M, Lian Q, Ge RS. Response to the Svingen Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health, 2016, 13, 246. Int J Environ Res Public Health. 2016 May 25;13(6). pii: E533. doi: 10.3390/ijerph13060533. PubMed PMID: 27231929; PubMed Central PMCID: PMC4923990.

5: Li X, Chen X, Hu G, Li L, Su H, Wang Y, Chen D, Zhu Q, Li C, Li J, Wang M, Lian Q, Ge RS. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int J Environ Res Public Health. 2016 Feb 23;13(3). pii: E246. doi: 10.3390/ijerph13030246. PubMed PMID: 26907321; PubMed Central PMCID: PMC4808909.

6: Svingen T. Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health 2016, 13, 246. Int J Environ Res Public Health. 2016 May 25;13(6). pii: E532. doi: 10.3390/ijerph13060532. PubMed PMID: 27231928; PubMed Central PMCID: PMC4923989.

7: Zhang M, Sheng Y. An indirect competitive fluorescence immunoassay for determination of dicyclohexyl phthalate in water samples. J Fluoresc. 2010 Nov;20(6):1167-73. doi: 10.1007/s10895-010-0663-8. PubMed PMID: 20390441.

8: Saillenfait AM, Gallissot F, Sabaté JP. Differential developmental toxicities of di-n-hexyl phthalate and dicyclohexyl phthalate administered orally to rats. J Appl Toxicol. 2009 Aug;29(6):510-21. doi: 10.1002/jat.1436. PubMed PMID: 19391110.

9: Yamasaki K, Okuda H, Takeuchi T, Minobe Y. Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats. Toxicol Lett. 2009 Aug 25;189(1):14-20. doi: 10.1016/j.toxlet.2009.04.023. Epub 2009 May 3. PubMed PMID: 19410640.

10: Lake BG, Foster JR, Collins MA, Stubberfield CR, Gangolli SD, Srivastava SP. Studies on the effects of orally administered dicyclohexyl phthalate in the rat. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):217-26. PubMed PMID: 7136727.

11: Hoshino N, Iwai M, Okazaki Y. A two-generation reproductive toxicity study of dicyclohexyl phthalate in rats. J Toxicol Sci. 2005 Dec;30 Spec No.:79-96. PubMed PMID: 16641545.

12: Zhang MC, Zhuang HS, Lang Q. [Study of dicyclohexyl phthalate on preparation and characterization of artificial antigen]. Wei Sheng Yan Jiu. 2006 Sep;35(5):543-6. Chinese. PubMed PMID: 17086698.

13: Wang J, Zhang L, Xin D, Yang Y. Dispersive Micro-Solid-Phase Extraction Based on Decanoic Acid Coated-Fe₃O₄ Nanoparticles for HPLC Analysis of Phthalate Esters in Liquor Samples. J Food Sci. 2015 Nov;80(11):C2452-8. doi: 10.1111/1750-3841.13101. Epub 2015 Oct 8. PubMed PMID: 26447907.

14: Wang X, Lou X, Zhang N, Ding G, Chen Z, Xu P, Wu L, Cai J, Han J, Qiu X. Phthalate esters in main source water and drinking water of Zhejiang Province (China): Distribution and health risks. Environ Toxicol Chem. 2015 Oct;34(10):2205-12. doi: 10.1002/etc.3065. Epub 2015 Aug 27. PubMed PMID: 25988232.

15: Mathieu-Denoncourt J, Martyniuk CJ, Loughery JR, Yargeau V, de Solla SR, Langlois VS. Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae. Environ Toxicol Chem. 2016 Oct;35(10):2511-2522. doi: 10.1002/etc.3413. Epub 2016 Jun 21. PubMed PMID: 26924002.

16: Ahbab MA, Güven C, Koçkaya EA, Barlas N. Comparative developmental toxicity evaluation of di- n-hexyl phthalate and dicyclohexyl phthalate in rats. Toxicol Ind Health. 2017 Sep;33(9):696-716. doi: 10.1177/0748233717711868. Epub 2017 Aug 31. PubMed PMID: 28854868.

17: Bradley EL, Burden RA, Leon I, Mortimer DN, Speck DR, Castle L. Determination of phthalate diesters in foods. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(4):722-34. doi: 10.1080/19440049.2013.781683. Epub 2013 Apr 24. PubMed PMID: 23614781.

18: Li K, Ma D, Wu J, Chai C, Shi Y. Distribution of phthalate esters in agricultural soil with plastic film mulching in Shandong Peninsula, East China. Chemosphere. 2016 Dec;164:314-321. doi: 10.1016/j.chemosphere.2016.08.068. Epub 2016 Sep 3. PubMed PMID: 27596820.

19: Zhou Q, Zheng Z, Xiao J, Fan H, Yan X. Determination of phthalate esters at trace level from environmental water samples by magnetic solid-phase extraction with Fe@SiO2@polyethyleneimine magnetic nanoparticles as adsorbent prior to high-performance liquid chromatography. Anal Bioanal Chem. 2016 Jul;408(19):5211-20. doi: 10.1007/s00216-016-9613-x. Epub 2016 May 14. PubMed PMID: 27178558.

20: Schecter A, Lorber M, Guo Y, Wu Q, Yun SH, Kannan K, Hommel M, Imran N, Hynan LS, Cheng D, Colacino JA, Birnbaum LS. Phthalate concentrations and dietary exposure from food purchased in New York State. Environ Health Perspect. 2013 Apr;121(4):473-94. doi: 10.1289/ehp.1206367. Epub 2013 Mar 6. PubMed PMID: 23461894; PubMed Central PMCID: PMC3620091.