LS-104

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 599288

CAS#: 368836-72-0

Description: LS-104 is a JAK2 inhibitor.

Chemical Structure

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LS-104
CAS# 368836-72-0
Instruction

Theoretical Analysis

MedKoo Cat#: 599288
Name: LS-104
CAS#: 368836-72-0
Chemical Formula: C19H16N2O3
Exact Mass: 320.12
Molecular Weight: 320.340
Elemental Analysis: C, 71.24; H, 5.03; N, 8.74; O, 14.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: LS-104; LS 104; LS104; Tyrene CR-4;

IUPAC/Chemical Name: (2E,4E)-N-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide

InChi Key: DTCCYSMPUUYHOF-LHQXNBGVSA-N

InChi Code: InChI=1S/C19H16N2O3/c20-12-16(19(24)21-13-15-5-2-1-3-6-15)8-4-7-14-9-10-17(22)18(23)11-14/h1-11,22-23H,13H2,(H,21,24)/b7-4+,16-8+

SMILES Code: O=C(NCC1=CC=CC=C1)/C(C#N)=C/C=C/C2=CC=C(O)C(O)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 320.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Thomas S, Aldlyami E, Gupta S, Reed MR, Muller SD, Partington PF. Unsuitability and high perforation rate of latex-free gloves in arthroplasty: a cause for concern. Arch Orthop Trauma Surg. 2011 Apr;131(4):455-8. doi: 10.1007/s00402-010-1146-8. Epub 2010 Jul 7. PubMed PMID: 20607254.

2: Lipka DB, Hoffmann LS, Heidel F, Markova B, Blum MC, Breitenbuecher F, Kasper S, Kindler T, Levine RL, Huber C, Fischer T. LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells. Mol Cancer Ther. 2008 May;7(5):1176-84. doi: 10.1158/1535-7163.MCT-07-2215. PubMed PMID: 18483305.

3: Kasper S, Breitenbuecher F, Hoehn Y, Heidel F, Lipka DB, Markova B, Huber C, Kindler T, Fischer T. The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia. Leuk Res. 2008 Nov;32(11):1698-708. doi: 10.1016/j.leukres.2008.05.003. Epub 2008 Jun 16. PubMed PMID: 18556063.