Mersalyl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461731

CAS#: 492-18-2

Description: Mersalyl is an organic mercurial diuretic.

Chemical Structure

img
Mersalyl
CAS# 492-18-2
Instruction

Theoretical Analysis

MedKoo Cat#: 461731
Name: Mersalyl
CAS#: 492-18-2
Chemical Formula: C13H16HgNNaO6
Exact Mass: 507.06
Molecular Weight: 505.850
Elemental Analysis: C, 30.87; H, 3.19; Hg, 39.65; N, 2.77; Na, 4.54; O, 18.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Mersalyl; Mercuramide; Diursal; Igrosin; Salurin; Salyrgan; Uragan;

IUPAC/Chemical Name: sodium (3-(2-(carboxymethoxy)benzamido)-2-methoxypropyl)oxidomercury

InChi Key: TVMSTPRSQZYYMF-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H16NO5.Hg.Na.O/c1-9(18-2)7-14-13(17)10-5-3-4-6-11(10)19-8-12(15)16;;;/h3-6,9H,1,7-8H2,2H3,(H,14,17)(H,15,16);;;/q;;+1;-1

SMILES Code: [O-][Hg]CC(OC)CNC(C1=CC=CC=C1OCC(O)=O)=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 505.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Joseph SK, Ryan SV, Pierson S, Renard-Rooney D, Thomas AP. The effect of mersalyl on inositol trisphosphate receptor binding and ion channel function. J Biol Chem. 1995 Feb 24;270(8):3588-93. PubMed PMID: 7533153.

2: García N, Martínez-Abundis E, Pavón N, Chávez E. On the opening of an insensitive cyclosporin A non-specific pore by phenylarsine plus mersalyl. Cell Biochem Biophys. 2007;49(2):84-90. PubMed PMID: 17906363.

3: Kolbe HV, Kadenbach B. Reaction of mersalyl with mitochondrial proteins under native and denaturing conditions as exemplified by the identification and isolation of the phosphate carrier. Hoppe Seylers Z Physiol Chem. 1981 Dec;362(12):1583-90. PubMed PMID: 7319473.

4: Agani F, Semenza GL. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol Pharmacol. 1998 Nov;54(5):749-54. PubMed PMID: 9804609.

5: BLACKMORE WP. Comparative effects of chlorothiazide and mersalyl (mersalyl sodium and theophylline) on the kidney. J Pharmacol Exp Ther. 1959 Apr;125(4):303-8. PubMed PMID: 13642272.

6: Thalhammer T, Graf J. Hepatobiliary transport of the anionic organomercury compound (mersalyl) is carrier mediated. Biochem Pharmacol. 1989 Oct 1;38(19):3223-31. PubMed PMID: 2818621.

7: Yoshida K, Kimura H. Mersalyl, a sulfhydryl reagent, alters the solubility of myosin and cytoskeletal proteins of human platelets. Biochim Biophys Acta. 1986 Feb 19;880(2-3):197-203. PubMed PMID: 2935197.

8: Diwan JJ, Aronson D, Gonsalves NO. Effect of mersalyl on mitochondrial Mg++ flux. J Bioenerg Biomembr. 1980 Aug;12(3-4):205-12. PubMed PMID: 7217041.

9: Mavier P, Hanoune J. Adenylate cyclase from rat-liver plasma membrane: inhibition by mersalyl and other mercurial derivatives. Eur J Biochem. 1975 Nov 15;59(2):593-9. PubMed PMID: 128456.

10: Kramer MJ, Cleeland R, Grunberg E. Mersalyl: a diuretic with antiviral properties. Antimicrob Agents Chemother. 1975 Sep;8(3):295-9. PubMed PMID: 810082; PubMed Central PMCID: PMC429309.

11: WEINER IM, MULLER OH. A polarographic study of mersalyl (salyrgan)-thiol complexes and of the excreted products of mersalyl. J Pharmacol Exp Ther. 1955 Mar;113(3):241-9. PubMed PMID: 14368491.

12: Kowaltowski AJ, Vercesi AE, Castilho RF. Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition. Biochim Biophys Acta. 1997 Feb 15;1318(3):395-402. PubMed PMID: 9048976.

13: Park CS, Doh PS, Lee CJ, Han DS, Carraway RE, Miller TB. Cellular mechanism of stimulation of renin secretion by the mercurial diuretic mersalyl. J Pharmacol Exp Ther. 1991 Apr;257(1):219-24. PubMed PMID: 1850465.

14: Fonyo A, Vignais PV. Phosphate carrier of liver mitochondria: the reaction of its SH groups with mersalyl, 5,5'-dithio-bis-nitrobenzoate, and N-ethylmaleimide and the modulation of reactivity by the energy state of the mitochondria. J Bioenerg Biomembr. 1980 Aug;12(3-4):137-49. PubMed PMID: 7217038.

15: Steven FS, Griffin MM. Studies on the molecular mechanism of mersalyl and 4-aminophenylmercuric acetate re-activation of trypsin-thiol complexes. Eur J Biochem. 1980 Aug;109(2):567-73. PubMed PMID: 7408902.

16: Hofmann HD, Kadenbach B. Specific labeling of a phosphate-transporting protein from rat-liver mitochondria by [203Hg]mersalyl. Eur J Biochem. 1979 Dec 17;102(2):605-13. PubMed PMID: 527595.

17: Muneoka Y, Shiba Y, Maetani T, Kanno Y. Further study on the effect of mersalyl, an organic mercurial, on relaxing response of a molluscan smooth muscle to monoamines. J Toxicol Sci. 1978 May;3(2):117-26. PubMed PMID: 755106.

18: Diwan JJ, Markoff M, Lehrer PH. Comparison of effects of mersalyl & N-ethyl maleimide on mitochondrial K+ flux. Indian J Biochem Biophys. 1977 Dec;14(4):342-6. PubMed PMID: 27451.

19: Brustovetsky N, Klingenberg M. The reconstituted ADP/ATP carrier can mediate H+ transport by free fatty acids, which is further stimulated by mersalyl. J Biol Chem. 1994 Nov 4;269(44):27329-36. PubMed PMID: 7961643.

20: Bansinath M, Bose AC, Hema S, Guruswami MN. Effect of mersalyl at cholinoceptive sites. Indian J Physiol Pharmacol. 1981 Jul-Sep;25(3):265-8. PubMed PMID: 7298152.