WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461696
CAS#: 134377-69-8
Description: Safironil is a antifibrotic compound and an inhibitor of prolyl 4-hydroxylase.
MedKoo Cat#: 461696
Name: Safironil
CAS#: 134377-69-8
Chemical Formula: C15H23N3O4
Exact Mass: 309.1689
Molecular Weight: 309.36
Elemental Analysis: C, 58.24; H, 7.49; N, 13.58; O, 20.69
This product is not in stock, which may be available by custom synthesis.
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Synonym: Safironil;
IUPAC/Chemical Name: N2,N4-bis(3-methoxypropyl)pyridine-2,4-dicarboxamide
InChi Key: HLSXICGBWKECLM-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H23N3O4/c1-21-9-3-6-17-14(19)12-5-8-16-13(11-12)15(20)18-7-4-10-22-2/h5,8,11H,3-4,6-7,9-10H2,1-2H3,(H,17,19)(H,18,20)
SMILES Code: O=C(C1=NC=CC(C(NCCCOC)=O)=C1)NCCCOC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 309.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wang YJ, Wang SS, Bickel M, Guenzler V, Gerl M, Bissell DM. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998 Jan;152(1):279-87. PubMed PMID: 9422545; PubMed Central PMCID: PMC1858123.
2: Shimizu I. Antifibrogenic therapies in chronic HCV infection. Curr Drug Targets Infect Disord. 2001 Aug;1(2):227-40. Review. PubMed PMID: 12455417.
