WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461673
Description: Sulfabromomethazine, also known as Bromosulfamethazine, NSC 5874, SN 3517, is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis.
MedKoo Cat#: 461673
Chemical Formula: C12H13BrN4O2S
Exact Mass: 355.9943
Molecular Weight: 357.22
Elemental Analysis: C, 40.35; H, 3.67; Br, 22.37; N, 15.68; O, 8.96; S, 8.97
Synonym: 5-Bromosulfamethazine; Bromosulfamethazine; NSC 5874; NSC-5874; NSC5874; SN 3517; SN-3517; SN3517; Sulfabrom ; Sulfabromomethazine;
IUPAC/Chemical Name: 4-amino-N-(5-bromo-4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
InChi Key: KWXCNODTHBHSIQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H13BrN4O2S/c1-7-11(13)8(2)16-12(15-7)17-20(18,19)10-5-3-9(14)4-6-10/h3-6H,14H2,1-2H3,(H,15,16,17)
SMILES Code: O=S(C1=CC=C(N)C=C1)(NC2=NC(C)=C(Br)C(C)=N2)=O
Appearance: Orange to light red solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in 1M sodium hydroxide, soluble in acetic acid, slightly soluble in DMSO and ethanol, not soluble in water.
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
|Biological target:||Sulfabrom (N 3517; Sulfabromomethazine) is a long-acting Sulfonamide that is used for the treatment of coccidiosis and various bacterial infections in the poultry, swine and cattle|
|In vitro activity:||TBD|
|In vivo activity:||TBD|
The following data is based on the product molecular weight 357.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
|In vitro protocol:||TBD|
|In vivo protocol:||TBD|
1: STOWE CM, ARONSON AL, JOHNSON K. The pharmacology of sulfabromomethazine, a new long-acting sulfonamide, in cattle. Am J Vet Res. 1958 Apr;19(71):345-53. PubMed PMID: 13533757.
2: Unruh J, Schwartz DP, Barford RA. Quantitation of sulfamethazine in pork tissue by thin-layer chromatography. J AOAC Int. 1993 Mar-Apr;76(2):335-41. PubMed PMID: 8471859.
3: Goodspeed DP, Simpson RM, Ashworth RB, Shafer JW, Cook HR. Sensitive and specific gas-liquid chromatographic-spectrophotometric screening procedure for trace levels of five sulfonamides in liver, kidney, and muscle tissue. J Assoc Off Anal Chem. 1978 Sep;61(5):1050-3. PubMed PMID: 721719.
4: Fink DW, Martin RP, Blodinger J. Facile separation of sulfonamides from their degradates by liquid--liquid extraction. J Pharm Sci. 1978 Oct;67(10):1415-9. PubMed PMID: 702292.
5: Thomas MH, Soroka KE, Thomas SH. Quantitative thin layer chromatographic multi-sulfonamide screening procedure. J Assoc Off Anal Chem. 1983 Jul;66(4):881-3. PubMed PMID: 6885694.
6: Manuel AJ, Steller WA. Gas-liquid chromatographic determination of sulfamethazine in swine and cattle tissues. J Assoc Off Anal Chem. 1981 Jul;64(4):794-9. PubMed PMID: 7275892.