Sulfabromomethazine | CAS#116-45-0 | sulfamezathine derivative

Sulfabromomethazine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461673

CAS#: 116-45-0

Description: Sulfabromomethazine, also known as Bromosulfamethazine, NSC 5874, SN 3517, is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis.

Chemical Structure

Sulfabromomethazine

CAS# 116-45-0

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 461673
Name: Sulfabromomethazine
CAS#: 116-45-0
Chemical Formula: C12H13BrN4O2S
Exact Mass: 355.99
Molecular Weight: 357.220
Elemental Analysis: C, 40.35; H, 3.67; Br, 22.37; N, 15.68; O, 8.96; S, 8.97

Price and Availability

Size	Price	Availability
10mg	USD 150	Ready to ship
25mg	USD 250	Ready to ship
50mg	USD 450	Ready to ship
100mg	USD 825	Ready to ship
200mg	USD 1550	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: 5-Bromosulfamethazine; Bromosulfamethazine; NSC 5874; NSC-5874; NSC5874; SN 3517; SN-3517; SN3517; Sulfabrom ; Sulfabromomethazine;

IUPAC/Chemical Name: 4-amino-N-(5-bromo-4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

InChi Key: KWXCNODTHBHSIQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H13BrN4O2S/c1-7-11(13)8(2)16-12(15-7)17-20(18,19)10-5-3-9(14)4-6-10/h3-6H,14H2,1-2H3,(H,15,16,17)

SMILES Code: O=S(C1=CC=C(N)C=C1)(NC2=NC(C)=C(Br)C(C)=N2)=O

Appearance: Orange to light red solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#YXM90828

QC Data:

View QC data: current batch, Lot#YXM90828

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	Sulfabromomethazine is a long-acting Sulfonamide that is used for the treatment of coccidiosis and various bacterial infections in poultry, swine, and cattle.
In vitro activity:	To be determined
In vivo activity:	To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 357.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	To be determined
In vitro protocol:	To be determined
In vivo protocol:	To be determined

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: STOWE CM, ARONSON AL, JOHNSON K. The pharmacology of sulfabromomethazine, a new long-acting sulfonamide, in cattle. Am J Vet Res. 1958 Apr;19(71):345-53. PubMed PMID: 13533757.

2: Unruh J, Schwartz DP, Barford RA. Quantitation of sulfamethazine in pork tissue by thin-layer chromatography. J AOAC Int. 1993 Mar-Apr;76(2):335-41. PubMed PMID: 8471859.

3: Goodspeed DP, Simpson RM, Ashworth RB, Shafer JW, Cook HR. Sensitive and specific gas-liquid chromatographic-spectrophotometric screening procedure for trace levels of five sulfonamides in liver, kidney, and muscle tissue. J Assoc Off Anal Chem. 1978 Sep;61(5):1050-3. PubMed PMID: 721719.

4: Fink DW, Martin RP, Blodinger J. Facile separation of sulfonamides from their degradates by liquid--liquid extraction. J Pharm Sci. 1978 Oct;67(10):1415-9. PubMed PMID: 702292.

5: Thomas MH, Soroka KE, Thomas SH. Quantitative thin layer chromatographic multi-sulfonamide screening procedure. J Assoc Off Anal Chem. 1983 Jul;66(4):881-3. PubMed PMID: 6885694.

6: Manuel AJ, Steller WA. Gas-liquid chromatographic determination of sulfamethazine in swine and cattle tissues. J Assoc Off Anal Chem. 1981 Jul;64(4):794-9. PubMed PMID: 7275892.

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