Ditophal

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461666

CAS#: 584-69-0

Description: Ditophal is an antileprotic drug.

Chemical Structure

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Ditophal
CAS# 584-69-0
Instruction

Theoretical Analysis

MedKoo Cat#: 461666
Name: Ditophal
CAS#: 584-69-0
Chemical Formula: C12H14O2S2
Exact Mass: 254.04
Molecular Weight: 254.360
Elemental Analysis: C, 56.66; H, 5.55; O, 12.58; S, 25.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ditophal; Etisul;

IUPAC/Chemical Name: S,S-diethyl benzene-1,3-bis(carbothioate)

InChi Key: DWGXUDUOJPYAOR-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14O2S2/c1-3-15-11(13)9-6-5-7-10(8-9)12(14)16-4-2/h5-8H,3-4H2,1-2H3

SMILES Code: O=C(C1=CC=CC(C(SCC)=O)=C1)SCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 254.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: SCHALLER KF, SERIE C. Ditophal in the treatment of leprosy. Lepr Rev. 1962 Jan;33:52-61. PubMed PMID: 14497999.

2: ELLARD GA, GARROD JM, SCALES B, SNOW GA. DISTRIBUTION, METABOLISM AND EXCRETION OF PERCUTANEOUSLY ADMINISTERED DITOPHAL ("ETISUL"). Biochem Pharmacol. 1965 Feb;14:129-38. PubMed PMID: 14332458.

3: Waters MF, Pettit JH. Chemotherapeutic trials in leprosy. 2. Comparative trial of dapsone plus ditophal (Etisul) and dapsone alone in the treatment of lepromatous leprosy. Int J Lepr. 1965 Jul-Sep;33(3):280-96. PubMed PMID: 5322767.

4: DAVIES GE, DRIVER GW. Action of two ethyl thiol esters against experimental tuberculosis in the guinea-pig. Br J Pharmacol Chemother. 1960 Mar;15:122-7. PubMed PMID: 13814392; PubMed Central PMCID: PMC1481979.