Amflutizole

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592804

CAS#: 82114-19-0

Description: Amflutizole is a Xanthine oxidase inhibitor used for the treatment of gout.

Chemical Structure

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Amflutizole
CAS# 82114-19-0
Instruction

Theoretical Analysis

MedKoo Cat#: 592804
Name: Amflutizole
CAS#: 82114-19-0
Chemical Formula: C11H7F3N2O2S
Exact Mass: 288.02
Molecular Weight: 288.240
Elemental Analysis: C, 45.84; H, 2.45; F, 19.77; N, 9.72; O, 11.10; S, 11.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Amflutizole

IUPAC/Chemical Name: 5-Isothiazolecarboxylic acid, 4-amino-3-(3-(trifluoromethyl)phenyl)-

InChi Key: KVMCEGAWQYTFKC-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H7F3N2O2S/c12-11(13,14)6-3-1-2-5(4-6)8-7(15)9(10(17)18)19-16-8/h1-4H,15H2,(H,17,18)

SMILES Code: O=C(C1=C(N)C(C2=CC=CC(C(F)(F)F)=C2)=NS1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 288.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Phillis JW, Sen S, Cao X. Amflutizole, a xanthine oxidase inhibitor, inhibits free radical generation in the ischemic/reperfused rat cerebral cortex. Neurosci Lett. 1994 Mar 14;169(1-2):188-90. PubMed PMID: 8047280.

2: O'Regan MH, Smith-Barbour M, Perkins LM, Cao X, Phillis JW. The effect of amflutizole, a xanthine oxidase inhibitor, on ischemia-evoked purine release and free radical formation in the rat cerebral cortex. Neuropharmacology. 1994 Oct;33(10):1197-201. PubMed PMID: 7862255.

3: Wortmann RL, Ridolfo AS, Lightfoot RW Jr, Fox IH. Antihyperuricemic properties of amflutizole in gout. J Rheumatol. 1985 Jun;12(3):540-3. PubMed PMID: 3900392.

4: Werns SW, Grum CM, Ventura A, Hahn RA, Ho PP, Towner RD, Fantone JC, Schork MA, Lucchesi BR. Xanthine oxidase inhibition does not limit canine infarct size. Circulation. 1991 Mar;83(3):995-1005. PubMed PMID: 1999047.

5: Millar AD, Rampton DS, Chander CL, Claxson AW, Blades S, Coumbe A, Panetta J, Morris CJ, Blake DR. Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis. Gut. 1996 Sep;39(3):407-15. PubMed PMID: 8949646; PubMed Central PMCID: PMC1383348.

6: Manning A, Bernier M, Crome R, Little S, Hearse D. Reperfusion-induced arrhythmias: a study of the role of xanthine oxidase-derived free radicals in the rat heart. J Mol Cell Cardiol. 1988 Jan;20(1):35-45. PubMed PMID: 3367377.

7: Sanders SA, Eisenthal R, Harrison R. NADH oxidase activity of human xanthine oxidoreductase--generation of superoxide anion. Eur J Biochem. 1997 May 1;245(3):541-8. PubMed PMID: 9182988.

8: Cazevieille C, Muller A, Meynier F, Dutrait N, Bonne C. Protection by prostaglandins from glutamate toxicity in cortical neurons. Neurochem Int. 1994 Apr;24(4):395-8. PubMed PMID: 7914788.

9: Singh D, Nazhat NB, Fairburn K, Sahinoglu T, Blake DR, Jones P. Electron spin resonance spectroscopic demonstration of the generation of reactive oxygen species by diseased human synovial tissue following ex vivo hypoxia-reoxygenation. Ann Rheum Dis. 1995 Feb;54(2):94-9. PubMed PMID: 7702413; PubMed Central PMCID: PMC1005529.