WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563654

CAS#: 138779-29-0

Description: ZM-181037 is an ATP-sensitive potassium channel-blocker and a eukalemic diuretic.

Chemical Structure

CAS# 138779-29-0

Theoretical Analysis

MedKoo Cat#: 563654
Name: ZM-181037
CAS#: 138779-29-0
Chemical Formula: C24H34N2O4
Exact Mass: 414.2519
Molecular Weight: 414.54
Elemental Analysis: C, 69.54; H, 8.27; N, 6.76; O, 15.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ZM-181037; ZM 181037; ZM181037; ICI-181037; ICI 181037; ICI181037;

IUPAC/Chemical Name: 2-[2-[(1R,2R)-1-(5-tert-Butyl-2-methoxyphenyl)-2-(dimethylamino)-1-hydroxypropyl]phenoxy]acetamide


InChi Code: InChI=1S/C24H34N2O4/c1-16(26(5)6)24(28,18-10-8-9-11-21(18)30-15-22(25)27)19-14-17(23(2,3)4)12-13-20(19)29-7/h8-14,16,28H,15H2,1-7H3,(H2,25,27)/t16-,24-/m1/s1

SMILES Code: O=C(N)COC1=CC=CC=C1[C@@](O)(C2=CC(C(C)(C)C)=CC=C2OC)[C@H](N(C)C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 414.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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1: Kau ST, Zografos P, Do ML, Halterman TJ, McConville MW, Yochim CL, Trivedi S, Howe BB, Li JH. Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic. Pharmacology. 1994 Oct;49(4):238-48. PubMed PMID: 7831387.

2: Kau S, Yochim C, Do ML, Leszczynska K, Andruskiewicz C, Schwartz J, Li J, Howe B. ICI 181,037: a novel eukalemic diuretic with antiarrhythmic activity. Jpn J Pharmacol. 1991 Nov;57(3):263-77. PubMed PMID: 1813657.