INH6 | CAS#1001753-24-7 | Hec1/Nek2 inhibitor

INH6
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563591

CAS#: 1001753-24-7

Description: INH6 is a cell-permeable Hec1/Nek2 Mitotic Pathway Inhibitor.

Chemical Structure

INH6

CAS# 1001753-24-7

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 563591
Name: INH6
CAS#: 1001753-24-7
Chemical Formula: C19H18N2OS
Exact Mass: 322.11
Molecular Weight: 322.426
Elemental Analysis: C, 70.78; H, 5.63; N, 8.69; O, 4.96; S, 9.94

Price and Availability

Size	Price	Availability
5mg	USD 150	2 Weeks
10mg	USD 250	2 Weeks
50mg	USD 600	2 Weeks
100mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: INH6; INH-6; INH 6; Hec1/Nek2 Mitotic Pathway Inhibitor II;

IUPAC/Chemical Name: N-[4-(2,4,6-Trimethylphenyl)-1,3-thiazol-2-yl]benzamide

InChi Key: WCZLNJTXHZPHLM-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18N2OS/c1-12-9-13(2)17(14(3)10-12)16-11-23-19(20-16)21-18(22)15-7-5-4-6-8-15/h4-11H,1-3H3,(H,20,21,22)

SMILES Code: O=C(NC1=NC(C2=C(C)C=C(C)C=C2C)=CS1)C3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	INH6 is a potent Nek2/Hec1 inhibitor; inhibits the growth of HeLa cells with an IC50 of 2.4 μM.
In vitro activity:	In MDA-MB-231 cells, Nek2 inhibition by INH6 reduced the β-catenin and Slug mRNA levels compared with control (Fig. 6a). Reference: Sci Rep. 2021 Apr 27;11(1):9016. https://pubmed.ncbi.nlm.nih.gov/33907253/
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.0	130.26
	Ethanol	6.0	18.61

Preparing Stock Solutions

The following data is based on the product molecular weight 322.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Rivera-Rivera Y, Marina M, Jusino S, Lee M, Velázquez JV, Chardón-Colón C, Vargas G, Padmanabhan J, Chellappan SP, Saavedra HI. The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. Sci Rep. 2021 Apr 27;11(1):9016. doi: 10.1038/s41598-021-88512-0. PMID: 33907253; PMCID: PMC8079711.
In vitro protocol:	1. Rivera-Rivera Y, Marina M, Jusino S, Lee M, Velázquez JV, Chardón-Colón C, Vargas G, Padmanabhan J, Chellappan SP, Saavedra HI. The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. Sci Rep. 2021 Apr 27;11(1):9016. doi: 10.1038/s41598-021-88512-0. PMID: 33907253; PMCID: PMC8079711.
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Pease C, Hutton B, Yazdi F, Wolfe D, Hamel C, Quach P, Skidmore B, Moher D, Alvarez GG. Efficacy and completion rates of rifapentine and isoniazid (3HP) compared to other treatment regimens for latent tuberculosis infection: a systematic review with network meta-analyses. BMC Infect Dis. 2017 Apr 11;17(1):265. doi: 10.1186/s12879-017-2377-x. Review. PubMed PMID: 28399802; PubMed Central PMCID: PMC5387294.

2: Niu Y, Song Y, Hou H, Zhu Y. Synthesis, structure, and large optical limiting effect of the first coordination polymeric cluster based on an {I@[AgI(inh)]6} hexagram block. Inorg Chem. 2005 Apr 4;44(7):2553-9. PubMed PMID: 15792494.

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