Rubratoxin A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461547

CAS#: 22467-31-8

Description: Rubratoxin A is a classical mycotoxin that acts as a PP2A-specific inhibitor.

Chemical Structure

img
Rubratoxin A
CAS# 22467-31-8
Instruction

Theoretical Analysis

MedKoo Cat#: 461547
Name: Rubratoxin A
CAS#: 22467-31-8
Chemical Formula: C26H32O11
Exact Mass: 520.19
Molecular Weight: 520.530
Elemental Analysis: C, 59.99; H, 6.20; O, 33.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Rubratoxin A;

IUPAC/Chemical Name: 4,8-dihydroxy-10-(hydroxy(6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl)-5-(1-hydroxyheptyl)-4,5,8,9,10,11-hexahydro-1H-cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione

InChi Key: XOEFANNJIKAWGX-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H32O11/c1-2-3-4-5-7-15(27)20-18-13(23(31)36-25(18)33)10-12(21(29)16-8-6-9-17(28)35-16)11-14-19(22(20)30)26(34)37-24(14)32/h6,9,12,15-16,20-23,27,29-31H,2-5,7-8,10-11H2,1H3

SMILES Code: O=C(C1=C2C(O)C(C(O)CCCCCC)C3=C(CC(C(C4CC=CC(O4)=O)O)C1)C(O)OC3=O)OC2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 520.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ishida M, Takeya K, Miyazu M, Yoshida A, Takai A. Force-inhibiting effect of Ser/Thr protein phosphatase 2A inhibitors on bovine ciliary muscle. J Smooth Muscle Res. 2015;51:10-21. PubMed PMID: 26727726; PubMed Central PMCID: PMC5137268.

2: Wada S, Usami I, Umezawa Y, Inoue H, Ohba S, Someno T, Kawada M, Ikeda D. Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis. Cancer Sci. 2010 Mar;101(3):743-50. doi: 10.1111/j.1349-7006.2009.01438.x. Epub 2009 Nov 14. PubMed PMID: 20028386.

3: Phillips TD, Hayes AW. Structural modification of polyfunctional rubratoxin B: effects on mammalian adenosine triphosphatase. J Environ Pathol Toxicol. 1979 Jan-Feb;2(3):853-60. PubMed PMID: 217944.

4: Unger PD, Hayes AW. High-pressure liquid chromatography of the mycotoxins, rubratoxins A and B, and its application to the analysis of urine and plasma for rubratoxin B. J Chromatogr. 1978 Jun 1;153(1):115-26. PubMed PMID: 580783.

5: Emeh CO, Marth EH. Bioproduction of rubratoxin in a glucose-mineral salts broth with nutritional supplements and metabolic inhibitors. Can J Microbiol. 1977 Dec;23(12):1695-9. PubMed PMID: 304372.

6: Emeh CO, Marth EH. Growth and synthesis of rubratoxin by Penicillium rubrum in a chemically defined medium fortified with organic acids and intermediates of the tricarboxylic acid cycle. Mycopathologia. 1976 Oct 22;59(3):137-42. PubMed PMID: 1036609.