Ronnel | CAS#299-84-3 | pesticide

Ronnel
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461208

CAS#: 299-84-3

Description: Ronnel is an organophosphate pesticide with growth-promoting properties.

Chemical Structure

Ronnel

CAS# 299-84-3

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 461208
Name: Ronnel
CAS#: 299-84-3
Chemical Formula: C8H8Cl3O3PS
Exact Mass: 319.90
Molecular Weight: 321.530
Elemental Analysis: C, 29.88; H, 2.51; Cl, 33.08; O, 14.93; P, 9.63; S, 9.97

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 350	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Ronnel; Dermafosu; Ectoral; Korlane; Nanchor; Fenchlorphos; Viozene; Trolene;

IUPAC/Chemical Name: O,O-dimethyl O-(2,4,5-trichlorophenyl) phosphorothioate

InChi Key: JHJOOSLFWRRSGU-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H8Cl3O3PS/c1-12-15(16,13-2)14-8-4-6(10)5(9)3-7(8)11/h3-4H,1-2H3

SMILES Code: S=P(OC)(OC1=CC(Cl)=C(Cl)C=C1Cl)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:

Product Data

Instruction:

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Biological target:	Ronnel is an inhibitor of the enzyme acetylcholinesterase (AChE). Ronnel is able to cause mitochondrial dysfunction.
In vitro activity:	The data from this study suggest that decreased conversion of thyroxine (T4) to triiodothyronine (T3) by propylthiouracil (PTU) or ronnel may be responsible for the increased plasma concentrations of T4 and slightly decreased plasma concentrations of T3 reported in steers treated with levels of both PTU and ronnel that are associated with growth stimulation. Reference: J Anim Sci. 1985 Jul;61(1):197-202. https://pubmed.ncbi.nlm.nih.gov/2411706/
In vivo activity:	This study found that ronnel was toxic to the development of heterozygous ATM allele (ATM8) flies. Ronnel did not affect the innate immune response of ATM8 flies, and it increased the already high levels of DNA damage in brains of ATM8 flies. Ronnel’s effects were not harmful to the lifespan of rescued ATM8 flies. Reference: PLoS One. 2018 Jan 16;13(1):e0190821. https://pubmed.ncbi.nlm.nih.gov/29338042/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	100.0	310.99

Preparing Stock Solutions

The following data is based on the product molecular weight 321.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Kahl S, Bitman J, Rumsey TS. In vitro studies of the effect of propylthiouracil and ronnel on thyroxine-5'-monodeiodinase activity in steers. J Anim Sci. 1985 Jul;61(1):197-202. doi: 10.2527/jas1985.611197x. PMID: 2411706. 2. Rimkus SA, Wassarman DA. A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant. PLoS One. 2018 Jan 16;13(1):e0190821. doi: 10.1371/journal.pone.0190821. PMID: 29338042; PMCID: PMC5770031.
In vitro protocol:	1. Kahl S, Bitman J, Rumsey TS. In vitro studies of the effect of propylthiouracil and ronnel on thyroxine-5'-monodeiodinase activity in steers. J Anim Sci. 1985 Jul;61(1):197-202. doi: 10.2527/jas1985.611197x. PMID: 2411706.
In vivo protocol:	1. Rimkus SA, Wassarman DA. A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant. PLoS One. 2018 Jan 16;13(1):e0190821. doi: 10.1371/journal.pone.0190821. PMID: 29338042; PMCID: PMC5770031.

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1: Kahl S, Bitman J, Rumsey TS. In vitro studies of the effect of propylthiouracil and ronnel on thyroxine-5'-monodeiodinase activity in steers. J Anim Sci. 1985 Jul;61(1):197-202. PubMed PMID: 2411706.

2: Trankina ML, Beitz DC, Trenkle AH. Effects of in vitro ronnel on metabolic activity in subcutaneous adipose tissue and skeletal muscle from steers. J Anim Sci. 1985 Mar;60(3):652-8. PubMed PMID: 2580822.

3: Rumsey TS, Tao H, Bitman J. Effects of ronnel on growth, endocrine function and blood measurements in steers and rats. J Anim Sci. 1981 Jul;53(1):217-25. PubMed PMID: 6172413.

4: Khera KS, Whalen C, Angers G. Teratogenicity study on pyrethrum and rotenone (natural origin) and ronnel in pregnant rats. J Toxicol Environ Health. 1982 Jul;10(1):111-9. PubMed PMID: 6182301.

5: DORNEY RS, TODD AC. Ronnel (trolene) as an anthelmintic in lambs. J Am Vet Med Assoc. 1959 Sep 15;135:336-8. PubMed PMID: 13817700.

6: Rumsey TS, Bitman J, Tao H. Changes in plasma concentrations of thyroxine, triiodothyronine, cholesterol and total lipid in beef steers fed ronnel. J Anim Sci. 1983 Jan;56(1):125-31. PubMed PMID: 6186657.

7: Runsey TS, Miller RW, Dinius DA. Residue content of beef feedlot manure after feeding diethylstilbestrol, chlortetracycline and Ronnel and the use of stirofos to reduce population of fly larvae in feedlot manure. Arch Environ Contam Toxicol. 1977;6(2-3):203-12. PubMed PMID: 71021.

8: KELLEY GW, MARSH CL. Lack of larvacidal action of Ronnel and Bayer 21/199 against migrating Ascaris suum in baby pigs. Am J Vet Res. 1960 Jan;21:109-10. PubMed PMID: 14405259.

9: Zalewska Z. Effect of intoxication of pregnant rats with ronnel on the activity of brain mitochondrial oxidoreductases in the progeny. Neuropatol Pol. 1980 May-Jun;18(2):219-26. PubMed PMID: 6158022.

10: Baker BB, Stannard AA, Yaskulski SG, Hirsh DC. Evaluation of topical application of ronnel solution for generalized demodicosis in dogs. J Am Vet Med Assoc. 1976 Jun 15;168(12):1105-7. PubMed PMID: 58853.

11: Sitkiewicz D, Skonieczna M, Rychła T, Gaździk D, Podymniak S, Bicz W. Modification of brain mitochondrial enzymes by the oxygen analogue of ronnel at various stages of development and aging. J Neurochem. 1982 Nov;39(5):1308-13. PubMed PMID: 6181202.

12: DeVaney JA, Ivie GW. Systemic activity of coumaphos, famphur, crufomate, ronnel, and phosmet given orally to hens for control of the northern fowl mite, Ornitbonyssus sulviarum (Canestrini and Fanzago). Poult Sci. 1980 Jun;59(6):1208-10. PubMed PMID: 6157151.

13: Wright FC. Method to determin ronnel and its oxygen analog in eggs. J Agric Food Chem. 1975 Jul-Aug;23(4):820-1. PubMed PMID: 49372.

14: Baughman RG, Jacobson RA. Crystal and molecular structure of organophosphorus insecticides. I. ronnel. J Agric Food Chem. 1975 Jul-Aug;23(4):811-5. PubMed PMID: 49371.

15: Bland RG. Toxicity of ronnel, dimethoate, and malathion to little house fly adults. J Econ Entomol. 1966 Dec;59(6):1435-7. PubMed PMID: 5976122.

16: Huggins D. [Inefficacy of K-7505 (Ronnel) in the treatment of schistosomiasis mansoni]. An Esc Nacl Saude Publica Med Trop (Lisb). 1971 Jan-Jun;5(1):43-5. Portuguese. PubMed PMID: 4109673.

17: Ivey MC, Claborn HV. Gas-liquid chromatographic determination of ronnel (O,O-dimethyl O-2,4,5-trichlorophenyl phosphorothioate) and the oxygen analog of ronnel (dimethyl 2,4,5-trichlorophenyl phosphate) in tissues of cattle. J Agric Food Chem. 1971 Nov-Dec;19(6):1256-8. PubMed PMID: 4108926.

18: Gehrt AJ. Methods for determining ronnel in feeds and mineral mixtures. J Assoc Off Anal Chem. 1972 Jul;55(4):710-3. PubMed PMID: 5056217.

19: Ivey MC, Mann HD, Wright FC. Ronnel and its oxygen analogue: residues in the body tissues and eggs of caged layers. J Econ Entomol. 1976 Dec 15;69(6):744-6. PubMed PMID: 63475.

20: Febles Vizcarrondo F, Ramos Morales F. Evaluation of Ronnel in schistosomiasis mansoni. Bol Asoc Med P R. 1966 Oct;58(10):500-4. PubMed PMID: 5341988.

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