Quinifur

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558502

CAS#: 101360-40-1

Description: Quinifur is a bioactive chemical.

Chemical Structure

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Quinifur
CAS# 101360-40-1
Instruction

Theoretical Analysis

MedKoo Cat#: 558502
Name: Quinifur
CAS#: 101360-40-1
Chemical Formula: C25H31N4O8P
Exact Mass: 546.19
Molecular Weight: 546.520
Elemental Analysis: C, 54.94; H, 5.72; N, 10.25; O, 23.42; P, 5.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Quinifur; Khinifur;

IUPAC/Chemical Name: 4-Quinolinecarboxamide, N-(4-(diethylamino)-1-methylbutylidene)-2-(2-(5-nitro-2-furanyl)ethenyl)-, phosphate (1:2)

InChi Key: FWFAAAZYGUDBFC-GOYNKABISA-N

InChi Code: InChI=1S/C25H28N4O4.H3O4P/c1-4-28(5-2)16-8-9-18(3)26-25(30)22-17-19(27-23-11-7-6-10-21(22)23)12-13-20-14-15-24(33-20)29(31)32;1-5(2,3)4/h6-7,10-15,17H,4-5,8-9,16H2,1-3H3;(H3,1,2,3,4)/b13-12+,26-18+;

SMILES Code: O=C(C1=CC(/C=C/C2=CC=C([N+]([O-])=O)O2)=NC3=CC=CC=C13)/N=C(C)/CCCN(CC)CC.O=P(O)(O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Daghastanli NA, Degterev IA, Tedesco AC, Borissevitch IE. Photocytotoxicity of a 5-nitrofuran-ethenyl-quinoline antiseptic (Quinifuryl) to P388 mouse leukemia cells. Braz J Med Biol Res. 2004 Dec;37(12):1873-9. Epub 2004 Nov 17. PubMed PMID: 15558194.

2: Degterev IA, Nogueira PC, Marsaioli AJ, Verces AE. Microsomal metabolism of quinifuryl--a nitrofuryl-ethenyl-quinolone antiseptic possessing antitumor activity in vitro. Eur J Drug Metab Pharmacokinet. 1999 Jan-Mar;24(1):15-22. PubMed PMID: 10412887.

3: Daghastanli NA, Rossa MM, Selistre-De-Araujo HS, Tedesco AC, Borissevitch IE, Degterev IA. Cytotoxicity of nitroheterocyclic compounds, quinifuryl and nitracrine, towards leukaemic and normal cells on the dark and under illumination with visible light. J Photochem Photobiol B. 2004 Jul 19;75(1-2):27-32. PubMed PMID: 15246347.

4: De Boni L, Correa DS, Silva DL, Gonçalves PJ, Zilio SC, Parra GG, Borissevitch IE, Canuto S, Mendonca CR. Experimental and theoretical study of two-photon absorption in nitrofuran derivatives: Promising compounds for photochemotherapy. J Chem Phys. 2011 Jan 7;134(1):014509. doi: 10.1063/1.3514911. PubMed PMID: 21219009.

5: Rossa MM, Rocha-e-Silva TA, Terruggi CH, Tedesco AC, Selistre-de-Araujo HS, Borissevich IE, Degterev IA. Comparison of the cytotoxicity of two nitroheterocyclic drugs (NHCD) towards transformed and non-transformed cells. Pharmacol Res. 2003 Oct;48(4):369-75. PubMed PMID: 12902207.

6: Buzukov AA, Il'asova VB, Tabak M, Meirelles NC, Degterev IA. An ESR and spectrophotometric study of the denitration of nitroheterocyclic drugs by liver homogenates and their metabolic consumption by liver microsomes from cytochrome P-450-induced mice. Chem Biol Interact. 1996 Mar 25;100(2):113-24. PubMed PMID: 8646785.

7: Blatun LA, Svetukhin AM, Pal'tsyn AA, Liapunov NA, Agafonov VA. [Clinico-laboratory effectiveness of modern ointments with a polyethylene glycol base in the treatment of purulent wounds]. Antibiot Khimioter. 1999;44(7):25-31. Review. Russian. PubMed PMID: 10494380.