Demethoxyrapamycin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461162

CAS#: 83482-58-0

Description: Demethoxyrapamycin is a new antifungal antibiotic which is co-produced with rapamycin by Streptomyces hygroscopicus.

Chemical Structure

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Demethoxyrapamycin
CAS# 83482-58-0
Instruction

Theoretical Analysis

MedKoo Cat#: 461162
Name: Demethoxyrapamycin
CAS#: 83482-58-0
Chemical Formula: C50H77NO12
Exact Mass: 883.54
Molecular Weight: 884.160
Elemental Analysis: C, 67.92; H, 8.78; N, 1.58; O, 21.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Demethoxyrapamycin; AY 24668; AY-24668; AY24668;

IUPAC/Chemical Name: Rapamycin, 32-demethoxy-

InChi Key: SRIDGLJAFSFWOP-NNGNFOKGSA-N

InChi Code: InChI=1S/C50H77NO12/c1-30-15-11-10-12-16-31(2)44(60-8)27-38-20-18-36(7)50(59,63-38)47(56)48(57)51-22-14-13-17-39(51)49(58)62-45(35(6)25-37-19-21-40(52)46(26-37)61-9)29-43(55)34(5)24-33(4)42(54)28-41(53)32(3)23-30/h10-12,15-16,24,30,32,34-40,42,44-46,52,54,59H,13-14,17-23,25-29H2,1-9H3/b12-10+,15-11+,31-16+,33-24+/t30-,32-,34+,35-,36-,37-,38-,39+,40-,42-,44-,45-,46+,50+/m0/s1

SMILES Code: C/C([C@@H](O)CC([C@@H](C)C[C@@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@H](CC[C@@H]1C)O[C@@]1(O)C2=O)=O)=C\[C@H](C(C[C@H](OC([C@@H]3N(CCCC3)C2=O)=O)[C@H](C[C@@H]4CC[C@H](O)[C@H](OC)C4)C)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 884.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sehgal SN, Baker H, Eng CP, Singh K, Vézina C. Demethoxyrapamycin (AY-24,668), a new antifungal antibiotic. J Antibiot (Tokyo). 1983 Apr;36(4):351-4. PubMed PMID: 6343327.

2: Eng CP, Sehgal SN, Vézina C. Activity of rapamycin (AY-22,989) against transplanted tumors. J Antibiot (Tokyo). 1984 Oct;37(10):1231-7. PubMed PMID: 6501094.

3: Feng Y, Zhang S, Poloyac S, Strom S, Venkataramanan R. Determination of 13-O-demethyl tacrolimus in human liver microsomal incubates using liquid chromatography-mass spectrometric assay (LC-MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jul 5;821(1):31-7. PubMed PMID: 15897019.