Echinoside B

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598321

CAS#: 75410-52-5

Description: Echinoside B exhibits anti-tumour activities in vitro and vivo.

Chemical Structure

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Echinoside B
CAS# 75410-52-5
Instruction

Theoretical Analysis

MedKoo Cat#: 598321
Name: Echinoside B
CAS#: 75410-52-5
Chemical Formula: C41H66NaO17S
Exact Mass: 0.00
Molecular Weight: 886.010
Elemental Analysis: C, 55.58; H, 7.51; Na, 2.59; O, 30.70; S, 3.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Echinoside B;

IUPAC/Chemical Name: sodium (3R,4R,5R,6S)-6-(((3S,5R,8R,10S,12S,13S,17R)-12,17-dihydroxy-17-((S)-2-hydroxy-6-methylheptan-2-yl)-4,4,10,14-tetramethyl-19-oxo-1,2,3,4,5,6,7,8,10,12,14,15,16,17-tetradecahydro-14l5-14,13-(epoxymethano)cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl sulfate

InChi Key: AJTCTPPHGQDTOH-BVFRRBAHSA-M

InChi Code: InChI=1S/C41H67O17S.Na/c1-20(2)10-9-14-38(7,48)39(49)16-17-41(8)23-11-12-25-36(4,5)27(13-15-37(25,6)22(23)18-26(42)40(39,41)35(47)57-41)55-34-32(29(44)24(19-53-34)58-59(50,51)52)56-33-31(46)30(45)28(43)21(3)54-33;/h18,20-21,23-34,42-46,48-49H,9-17,19H2,1-8H3,(H,50,51,52);/q;+1/p-1/t21-,23-,24-,25+,26+,27+,28-,29+,30+,31-,32-,33+,34+,37-,38+,39+,40+;/m1./s1

SMILES Code: CC1(C)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H](CO2)OS(=O)([O-])=O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](C)O3)O)O)O)CC[C@]4(C)C5=C[C@H](O)[C@]6(C(O7)=O)[C@]([C@@](C)(O)CCCC(C)C)(O)CCC67(C)[C@]5([H])CC[C@@]14[H].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 886.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhao Q, Xue Y, Wang JF, Li H, Long TT, Li Z, Wang YM, Dong P, Xue CH. In vitro and in vivo anti-tumour activities of echinoside A and ds-echinoside A from Pearsonothuria graeffei. J Sci Food Agric. 2012 Mar 15;92(4):965-74. doi: 10.1002/jsfa.4678. Epub 2011 Oct 19. PubMed PMID: 22012678.

2: Melek FR, Tadros MM, Yousif F, Selim MA, Hassan MH. Screening of marine extracts for schistosomicidal activity in vitro. Isolation of the triterpene glycosides echinosides A and B with potential activity from the Sea Cucumbers Actinopyga echinites and Holothuria polii. Pharm Biol. 2012 Apr;50(4):490-6. doi: 10.3109/13880209.2011.615842. Epub 2011 Dec 2. PubMed PMID: 22136393.

3: Yamasaki Y, Ito K, Enomoto Y, Sutko JL. Alterations by saponins of passive Ca2+ permeability and Na+-Ca2+ exchange activity of canine cardiac sarcolemmal vesicles. Biochim Biophys Acta. 1987 Mar 12;897(3):481-7. PubMed PMID: 3814597.

4: Enomoto Y, Ito K, Kawagoe Y, Morio Y, Yamasaki Y. Positive inotropic action of saponins on isolated atrial and papillary muscles from the guinea-pig. Br J Pharmacol. 1986 May;88(1):259-67. PubMed PMID: 3708218; PubMed Central PMCID: PMC1917120.

5: Kitagawa I, Kobayashi M, Inamoto T, Fuchida M, Kyogoku Y. Marine natural products. XIV. Structures of echinosides A and B, antifungal lanostane-oligosides from the sea cucumber Actinopyga echinites (Jaeger). Chem Pharm Bull (Tokyo). 1985 Dec;33(12):5214-24. PubMed PMID: 3833380.