Dup 747

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461131

CAS#: 142515-44-4

Description: Dup 747 is an analgesic drug that binds with high affinity and selectivity to the kappa-opioid receptor.

Chemical Structure

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Dup 747
CAS# 142515-44-4
Instruction

Theoretical Analysis

MedKoo Cat#: 461131
Name: Dup 747
CAS#: 142515-44-4
Chemical Formula: C24H28Cl2N2O2
Exact Mass: 446.15
Molecular Weight: 447.400
Elemental Analysis: C, 64.43; H, 6.31; Cl, 15.85; N, 6.26; O, 7.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Dup 747; Dup-747; Dup747;

IUPAC/Chemical Name: 2-(3,4-dichlorophenyl)-N-((1R,2R)-5-methoxy-2-(pyrrolidin-1-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methylacetamide

InChi Key: SYOPRZWROBOKGX-ZJSXRUAMSA-N

InChi Code: InChI=1S/C24H28Cl2N2O2/c1-27(23(29)15-16-8-10-19(25)20(26)14-16)24-18-6-5-7-22(30-2)17(18)9-11-21(24)28-12-3-4-13-28/h5-8,10,14,21,24H,3-4,9,11-13,15H2,1-2H3/t21-,24-/m1/s1

SMILES Code: Clc1ccc(CC(N(C)[C@H]2[C@H](N3CCCC3)CCc4c2cccc4OC)=O)cc1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 447.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Holtzman SG, Steinfels GF, Schmidt WK. Assessing spiradoline-like discriminative effects of DuP 747: influence of route of administration. Pharmacol Biochem Behav. 1994 Mar;47(3):487-91. PubMed PMID: 8208766.

2: Raghavan K, Dwivedi A, Campbell GC Jr, Nemeth G, Hussain MA. A spectroscopic investigation of DuP 747 polymorphs. J Pharm Biomed Anal. 1994 Jun;12(6):777-85. PubMed PMID: 7918780.

3: Hussain MA, Wu LS, Koval C, Hurwitz AR. Parenteral formulation of the kappa agonist analgesic, DuP 747, via micellar solubilization. Pharm Res. 1992 Jun;9(6):750-2. PubMed PMID: 1409356.

4: Holtzman SG. Further characterization of the discriminative stimulus effects of spiradoline. Pharmacol Biochem Behav. 2000 Jul;66(3):517-22. PubMed PMID: 10899364.