Diflumidone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461094

CAS#: 22736-85-2

Description: Diflumidone is a non-steroidal antiinflammatory drug.

Chemical Structure

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Diflumidone
CAS# 22736-85-2
Instruction

Theoretical Analysis

MedKoo Cat#: 461094
Name: Diflumidone
CAS#: 22736-85-2
Chemical Formula: C14H11F2NO3S
Exact Mass: 311.04
Molecular Weight: 311.300
Elemental Analysis: C, 54.02; H, 3.56; F, 12.21; N, 4.50; O, 15.42; S, 10.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Diflumidone; R 807; R-807; R807;

IUPAC/Chemical Name: N-(3-benzoylphenyl)-1,1-difluoromethanesulfonamide

InChi Key: JLBDOSAQLCZTSX-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11F2NO3S/c15-14(16)21(19,20)17-12-8-4-7-11(9-12)13(18)10-5-2-1-3-6-10/h1-9,14,17H

SMILES Code: O=S(Nc1cc(C(c2ccccc2)=O)ccc1)(C(F)F)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 311.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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Dilution Calculator

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1: Gomez EC, Trancik RJ. Effect of topical diflumidone on ultraviolet-light-induced erythema. Dermatologica. 1981;162(3):175-82. PubMed PMID: 7250461.

2: Xiong HY, Bayle A, Pannecoucke X, Besset T. An Electrophilic Reagent for the Direct Introduction of the SCF(2) PO(OEt)(2) Group to Molecules. Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13490-13494. doi: 10.1002/anie.201607231. Epub 2016 Sep 26. PubMed PMID: 27667673.

3: Vigdahl RL, Tukey RH. Mechanism of action of novel anti-inflammmatory drugs diflumidone and R-805. Biochem Pharmacol. 1977 Feb 15;26(4):307-11. PubMed PMID: 403918.

4: Swingle KF, Hamilton RR, Harrington JK, Kvam DC. 3-Benzoyldifluoromethanesulfonanilide, sodium salt (diflumidone sodium, MBR 4164-8): a new anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1971 Jan;189(1):129-44. PubMed PMID: 5130145.