Thiobarbituric acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592305

CAS#: 504-17-6

Description: Thiobarbituric acid has Antibacterial Activity.


Chemical Structure

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Thiobarbituric acid
CAS# 504-17-6

Theoretical Analysis

MedKoo Cat#: 592305
Name: Thiobarbituric acid
CAS#: 504-17-6
Chemical Formula: C4H4N2O2S
Exact Mass: 144.00
Molecular Weight: 144.150
Elemental Analysis: C, 33.33; H, 2.80; N, 19.43; O, 22.20; S, 22.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Thiobarbituric acid; NSC 4733; NSC-4733; NSC4733

IUPAC/Chemical Name: 2-Thiobarbituric acid

InChi Key: RVBUGGBMJDPOST-UHFFFAOYSA-N

InChi Code: InChI=1S/C4H4N2O2S/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)

SMILES Code: S=C(NC(C1)=O)NC1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 144.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Albericio F, Sharma A, Noki S, Zamisa SJ, Hazzah H, Almarhoon ZM, El-Faham A, de la Torre BG. Exploiting Thiobarbituric Acid Scaffold for Antibacterial Activity. ChemMedChem. 2018 Jul 13. doi: 10.1002/cmdc.201800414. [Epub ahead of print] PubMed PMID: 30004647.

2: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501301/ PubMed PMID: 30000360.

3: Ren XS, Ding W, Yang XY. [Icariin alleviates lipid peroxidation after spinal cord injury in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jun 20;38(6):711-715. Chinese. PubMed PMID: 29997094.

4: Mithun M, Rajashekaraiah V. L-Carnitine as an additive in Tyrode's buffer during platelet storage. Blood Coagul Fibrinolysis. 2018 Jul 10. doi: 10.1097/MBC.0000000000000760. [Epub ahead of print] PubMed PMID: 29995655.

5: Putburee R, Jetsrisuparb A, Fucharoen S, Tripatara A. Mitochondrial ferritin expression in erythroid cells from patients with alpha-thalassaemia. Hematology. 2018 Jul 11:1-5. doi: 10.1080/10245332.2018.1496812. [Epub ahead of print] PubMed PMID: 29993346.

6: Lozano-Paniagua D, Parrón T, Alarcón R, Requena M, Gil F, López-Guarnido O, Lacasaña M, Hernández AF. Biomarkers of oxidative stress in blood of workers exposed to non-cholinesterase inhibiting pesticides. Ecotoxicol Environ Saf. 2018 Jul 4;162:121-128. doi: 10.1016/j.ecoenv.2018.06.074. [Epub ahead of print] PubMed PMID: 29990723.

7: Subramanian V, Ravichandran A, Thiagarajan N, Govindarajan M, Dhandayuthapani S, Suresh S. Seminal reactive oxygen species and total antioxidant capacity: Correlations with sperm parameters and impact on male infertility. Clin Exp Reprod Med. 2018 Jun;45(2):88-93. doi: 10.5653/cerm.2018.45.2.88. Epub 2018 Jun 29. PubMed PMID: 29984209; PubMed Central PMCID: PMC6030612.

8: Boroujeni LS, Hojjatoleslamy M. Using Thymus carmanicus and Myrtus communis essential oils to enhance the physicochemical properties of potato chips. Food Sci Nutr. 2018 Apr 16;6(4):1006-1014. doi: 10.1002/fsn3.597. eCollection 2018 Jun. PubMed PMID: 29983964; PubMed Central PMCID: PMC6021700.

9: Azimzadeh B, Jahadi M. Effect of chitosan edible coating with Laurus nobilis extract on shelf life of cashew. Food Sci Nutr. 2018 Mar 23;6(4):871-877. doi: 10.1002/fsn3.630. eCollection 2018 Jun. PubMed PMID: 29983949; PubMed Central PMCID: PMC6021704.

10: Lyu F, Gao F, Ding Y. Effects of gamma radiation combined with cinnamon oil on qualities of smoked salmon slices inoculated with Shewanella putrefaciens. Food Sci Nutr. 2018 Mar 13;6(4):806-813. doi: 10.1002/fsn3.608. eCollection 2018 Jun. PubMed PMID: 29983943; PubMed Central PMCID: PMC6021692.

11: Glodde F, Günal M, Kinsel ME, AbuGhazaleh A. Effects of Natural Antioxidants on The Stability of Omega-3 Fatty Acids in Dog Food. J Vet Res. 2018 Mar 30;62(1):103-108. doi: 10.1515/jvetres-2018-0014. eCollection 2018 Mar. PubMed PMID: 29978134; PubMed Central PMCID: PMC5957468.

12: Zhu F, Zhong X, Zhou Y, Hou Z, Hu H, Liang L, Chen J, Chen Q, Ji X, Shang D. Protective effects of nicorandil against cerebral injury in a swine cardiac arrest model. Exp Ther Med. 2018 Jul;16(1):37-44. doi: 10.3892/etm.2018.6136. Epub 2018 May 7. PubMed PMID: 29977355; PubMed Central PMCID: PMC6030868.

13: Li X, Wang X, Liu J, Xu D, Cao Y, Sun B. The effect of unadsorbed proteins on the physiochemical properties of the heteroaggregates of oppositely charged lactoferrin coated lutein droplets and whey protein isolate coated DHA droplets. Food Funct. 2018 Jul 5. doi: 10.1039/c8fo00371h. [Epub ahead of print] PubMed PMID: 29974102.

14: Zhang S, Gilbert ER, Saremi B, Wong EA. Supplemental methionine sources have a neutral impact on oxidative status in broiler chickens. J Anim Physiol Anim Nutr (Berl). 2018 Jul 3. doi: 10.1111/jpn.12946. [Epub ahead of print] PubMed PMID: 29968941.

15: Kamel A, Hamouli-Said Z. Neonatal exposure to T3 disrupts male reproductive functions by altering redox homeostasis in immature testis of rats. Andrologia. 2018 Jul 2:e13082. doi: 10.1111/and.13082. [Epub ahead of print] PubMed PMID: 29968296.

16: Zych M, Kaczmarczyk-Sedlak I, Wojnar W, Folwarczna J. The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats. Oxid Med Cell Longev. 2018 Jun 4;2018:9274246. doi: 10.1155/2018/9274246. eCollection 2018. PubMed PMID: 29967666; PubMed Central PMCID: PMC6008867.

17: Zhao G, Zhao Y, Yu X, Kiprotich F, Han H, Guan R, Wang R, Shen W. Nitric Oxide Is Required for Melatonin-Enhanced Tolerance against Salinity Stress in Rapeseed (Brassica napus L.) Seedlings. Int J Mol Sci. 2018 Jun 29;19(7). pii: E1912. doi: 10.3390/ijms19071912. PubMed PMID: 29966262.

18: Xie H, Zhou D, Hu X, Liu Z, Song L, Zhu BW. Changes in lipid profiles of dried clams (Mactra chinensis Philippi and Ruditapes philippinarum) during accelerated storage and prediction of shelf life. J Agric Food Chem. 2018 Jul 2. doi: 10.1021/acs.jafc.8b03047. [Epub ahead of print] PubMed PMID: 29965751.

19: Stvolinsky SL, Antonova NA, Kulikova OI, Lopachev AV, Abaimov DA, Al-Baidani I, Lopacheva OM, Fedorova TN, Kaplun AP, Sorokoumova GM. [Lipoilcarnosine: synthesis, study of physico-chemical and antioxidant properties, biological activity]. Biomed Khim. 2018 Jun;64(3):268-275. doi: 10.18097/PBMC20186403268. Russian. PubMed PMID: 29964264.

20: Ferrúa CP, Leal FB, de Oliveira Gazal M, Ghisleni GC, de Carvalho RV, Demarco FF, Ogliari FA, Nedel F. Iodonium salt incorporation in dental adhesives and its relation with degree of conversion, ultimate tensile strength, cell viability, and oxidative stress. Clin Oral Investig. 2018 Jul 1. doi: 10.1007/s00784-018-2527-6. [Epub ahead of print] PubMed PMID: 29961139.