CL 242817

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597856

CAS#: 86709-48-0

Description: CL 242817 is an angiotensin converting enzyme (ACE) inhibitor.

Chemical Structure

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CL 242817
CAS# 86709-48-0
Instruction

Theoretical Analysis

MedKoo Cat#: 597856
Name: CL 242817
CAS#: 86709-48-0
Chemical Formula: C18H21NO5S
Exact Mass: 363.11
Molecular Weight: 363.420
Elemental Analysis: C, 59.49; H, 5.82; N, 3.85; O, 22.01; S, 8.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CL 242817; CL-242817; CL242817;

IUPAC/Chemical Name: ((2R,3S)-3-(acetylthio)-2-methyl-4-oxo-4-phenylbutanoyl)-L-proline

InChi Key: FLRNAFWKDUMBPC-PJODQICGSA-N

InChi Code: InChI=1S/C18H21NO5S/c1-11(17(22)19-10-6-9-14(19)18(23)24)16(25-12(2)20)15(21)13-7-4-3-5-8-13/h3-5,7-8,11,14,16H,6,9-10H2,1-2H3,(H,23,24)/t11-,14-,16-/m0/s1

SMILES Code: O=C(O)[C@H]1N(C([C@@H](C)[C@H](SC(C)=O)C(C2=CC=CC=C2)=O)=O)CCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 363.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ward WF, Molteni A, Ts'ao CH. Radiation-induced endothelial dysfunction and fibrosis in rat lung: modification by the angiotensin converting enzyme inhibitor CL242817. Radiat Res. 1989 Feb;117(2):342-50. PubMed PMID: 2922477.

2: Ward WF, Molteni A, Ts'ao CH, Kim YT, Hinz JM. Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme. Int J Radiat Oncol Biol Phys. 1992;22(3):623-5. PubMed PMID: 1735701.

3: Catravas JD, Ryan JW, Chung AY, Quinn NE, Anthony BL. Inhibition of endothelial-bound angiotensin converting enzyme, in vivo. Br J Pharmacol. 1990 Sep;101(1):121-7. PubMed PMID: 2282454; PubMed Central PMCID: PMC1917633.

4: Molteni A, Ward WF, Ts'ao CH, Solliday NH. Monocrotaline-induced cardiopulmonary damage in rats: amelioration by the angiotensin-converting enzyme inhibitor CL242817. Proc Soc Exp Biol Med. 1986 Sep;182(4):483-93. PubMed PMID: 3016747.