GR 100679

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597748

CAS#: 150351-87-4

Description: GR 100679 is a NK2 receptor antagonist.

Chemical Structure

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GR 100679
CAS# 150351-87-4
Instruction

Theoretical Analysis

MedKoo Cat#: 597748
Name: GR 100679
CAS#: 150351-87-4
Chemical Formula: C34H44N6O5
Exact Mass: 616.34
Molecular Weight: 616.760
Elemental Analysis: C, 66.21; H, 7.19; N, 13.63; O, 12.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GR 100679; GR-100679; GR100679;

IUPAC/Chemical Name: N-((3S,7R,10S)-7-((1H-indol-3-yl)methyl)-3-benzyl-2,10-dimethyl-4,6,9,12-tetraoxo-2,5,8,11-tetraazatridecan-13-yl)cyclohexanecarboxamide

InChi Key: IBEKIBIBZTXBOZ-GJDOKZOISA-N

InChi Code: InChI=1S/C34H44N6O5/c1-22(37-30(41)21-36-32(43)24-14-8-5-9-15-24)31(42)38-28(19-25-20-35-27-17-11-10-16-26(25)27)33(44)39-34(45)29(40(2)3)18-23-12-6-4-7-13-23/h4,6-7,10-13,16-17,20,22,24,28-29,35H,5,8-9,14-15,18-19,21H2,1-3H3,(H,36,43)(H,37,41)(H,38,42)(H,39,44,45)/t22-,28+,29-/m0/s1

SMILES Code: O=C(NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](C)NC(CNC(C3CCCCC3)=O)=O)=O)=O)[C@H](CC4=CC=CC=C4)N(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 616.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stratton SC, Beresford IJ, Harvey FJ, Turpin MP, Hagan RM, Tyers MB. Anxiolytic activity of tachykinin NK2 receptor antagonists in the mouse light-dark box. Eur J Pharmacol. 1993 Dec 21;250(3):R11-2. PubMed PMID: 7906655.

2: Beresford IJ, Sheldrick RL, Ball DI, Turpin MP, Walsh DM, Hawcock AB, Coleman RA, Hagan RM, Tyers MB. GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur J Pharmacol. 1995 Jan 16;272(2-3):241-8. PubMed PMID: 7713168.

3: Lundstrom K, Mills A, Allet E, Ceszkowski K, Agudo G, Chollet A, Liljestrom P. High-level expression of G protein-coupled receptors with the aid of the Semliki Forest virus expression system. J Recept Signal Transduct Res. 1995 Jan-Mar;15(1-4):23-32. PubMed PMID: 8903928.

4: Hagan RM, Beresford IJ, Stables J, Dupere J, Stubbs CM, Elliott PJ, Sheldrick RL, Chollet A, Kawashima E, McElroy AB, et al. Characterisation, CNS distribution and function of NK2 receptors studied using potent NK2 receptor antagonists. Regul Pept. 1993 Jul 2;46(1-2):9-19. PubMed PMID: 8210508.

5: Stables JM, Beresford IJ, Arkinstall S, Ireland SJ, Walsh DM, Seale PW, Ward P, Hagan RM. GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors. Neuropeptides. 1994 Dec;27(6):333-41. PubMed PMID: 7534879.