BC 197

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597743

CAS#: 115295-08-4

Description: BC 197 is a selective CCK-B agonist.

Chemical Structure

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BC 197
CAS# 115295-08-4
Instruction

Theoretical Analysis

MedKoo Cat#: 597743
Name: BC 197
CAS#: 115295-08-4
Chemical Formula: C60H81N11O17S
Exact Mass: 1,259.55
Molecular Weight: 1,260.420
Elemental Analysis: C, 57.18; H, 6.48; N, 12.22; O, 21.58; S, 2.54

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BC 197; BC-197; BC197; Boc-asp-tyr(SO3H)-ahx-lys-trp-ahx-asp-phe-NH2;

IUPAC/Chemical Name: (2S,5S,8R,11S,14S,17S,20S,24R)-11-((1H-indol-3-yl)methyl)-2-amino-8-(4-aminobutyl)-20-benzyl-5-((E)-buta-1,3-dien-1-yl)-24-((tert-butoxycarbonyl)amino)-14-butyl-1-(4-hydroxyphenyl)-3,9,12,15,18,21,23-heptaoxo-17-(2-oxo-2-(sulfooxy)ethyl)-4,7,10,13,16,19,22-heptaazahexacosan-26-oic acid

InChi Key: KUPOETRFWZHGEM-LAZFATJSSA-N

InChi Code: 1S/C60H81N11O17S/c1-6-8-19-39(65-52(76)42(62)29-37-24-26-40(72)27-25-37)35-64-44(23-15-16-28-61)53(77)68-47(31-38-34-63-43-22-14-13-20-41(38)43)55(79)66-45(21-9-7-2)54(78)69-49(33-51(75)88-89(84,85)86)56(80)67-46(30-36-17-11-10-12-18-36)57(81)71-58(82)48(32-50(73)74)70-59(83)87-60(3,4)5/h6,8,10-14,17-20,22,24-27,34,39,42,44-49,63-64,72H,1,7,9,15-16,21,23,28-33,35,61-62H2,2-5H3,(H,65,76)(H,66,79)(H,67,80)(H,68,77)(H,69,78)(H,70,83)(H,73,74)(H,71,81,82)(H,84,85,86)/b19-8+/t39-,42-,44+,45-,46-,47-,48+,49-/m0/s1

SMILES Code: CCCC[C@H](NC([C@@H](NC([C@H](NC[C@@H](NC([C@@H](N)Cc1ccc(O)cc1)=O)/C=C/C=C)CCCCN)=O)Cc2c3ccccc3[nH]c2)=O)C(N[C@H](C(N[C@H](C(NC([C@H](NC(OC(C)(C)C)=O)CC(O)=O)=O)=O)Cc4ccccc4)=O)CC(OS(=O)(O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,260.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Derrien M, McCort-Tranchepain I, Ducos B, Roques BP, Durieux C. Heterogeneity of CCK-B receptors involved in animal models of anxiety. Pharmacol Biochem Behav. 1994 Sep;49(1):133-41. PubMed PMID: 7816864.

2: Léna I, Simon H, Roques BP, Daugé V. Opposing effects of two CCK(B) agonists on the retrieval phase of a two-trial memory task after systemic injection in the rat. Neuropharmacology. 1999 Apr;38(4):543-53. PubMed PMID: 10221758.

3: Léna I, Roques BP, Durieux C. Dual modulation of dopamine release from anterior nucleus accumbens through cholecystokinin-B receptor subsites. J Neurochem. 1997 Jan;68(1):162-8. PubMed PMID: 8978722.

4: Heidbreder C, Roques BP, De Witte P. Similar potencies of CCK-8 and its analogue BOC(Nle28;Nle31)CCK27-33 on the self-stimulation behaviour both are antagonized by a newly synthesized cyclic CCK analogue. Neuropeptides. 1989 Feb-Mar;13(2):89-94. PubMed PMID: 2739884.

5: Derrien M, Durieux C, Roques BP. Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole. Br J Pharmacol. 1994 Mar;111(3):956-60. PubMed PMID: 8019773; PubMed Central PMCID: PMC1910081.

6: Léna I, Dh tel H, Garbay C, Daugé V. Involvement of D2 dopamine receptors in the opposing effects of two CCK-B agonists in a spatial recognition memory task: role of the anterior nucleus accumbens. Psychopharmacology (Berl). 2001 Jan 1;153(2):170-9. PubMed PMID: 11205416.

7: Durieux C, Derrien M, Maldonado R, Valverde O, Blommaert A, Fournié-Zaluski MC, Roques BP. CCK-B antagonists exhibit antidepressant-like effects and potentiate endogenous enkephalin analgesia. Correlation with in vivo binding affinities and brain penetration. Ann N Y Acad Sci. 1994 Mar 23;713:355-7. PubMed PMID: 8185186.

8: Ladurelle N, Sebret A, Garbay C, Roques BP, Daugé V. Opposite effects of CCK(B) agonists in grooming behaviour in rats: further evidence for two CCK(B) subsites. Br J Pharmacol. 1998 Jul;124(6):1091-8. PubMed PMID: 9720778; PubMed Central PMCID: PMC1565489.