GR 94800

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597680

CAS#: 141636-65-9

Description: GR 94800 is a selective NK2 heptapeptide antagonist.

Chemical Structure

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GR 94800
CAS# 141636-65-9
Instruction

Theoretical Analysis

MedKoo Cat#: 597680
Name: GR 94800
CAS#: 141636-65-9
Chemical Formula: C49H61N9O8
Exact Mass: 903.46
Molecular Weight: 904.080
Elemental Analysis: C, 65.10; H, 6.80; N, 13.94; O, 14.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GR 94800; G- 94800; GR94800; Nalpha-Benzoyl-ala-ala-D-trp-phe-D-pro-pro-nle-NH2;

IUPAC/Chemical Name: (S)-N-((S)-1-amino-1-oxohexan-2-yl)-1-(benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl)pyrrolidine-2-carboxamide

InChi Key: CWEISCOCKRHHOU-UJYVDGJVSA-N

InChi Code: InChI=1S/C49H61N9O8/c1-4-5-21-37(42(50)59)54-47(64)40-23-14-25-57(40)49(66)41-24-15-26-58(41)48(65)39(27-32-16-8-6-9-17-32)56-46(63)38(28-34-29-51-36-22-13-12-20-35(34)36)55-44(61)31(3)52-43(60)30(2)53-45(62)33-18-10-7-11-19-33/h6-13,16-20,22,29-31,37-41,51H,4-5,14-15,21,23-28H2,1-3H3,(H2,50,59)(H,52,60)(H,53,62)(H,54,64)(H,55,61)(H,56,63)/t30-,31-,37-,38+,39-,40-,41+/m0/s1

SMILES Code: CCCC[C@@H](C(N)=O)NC([C@H]1N(C([C@@H]2N(C([C@H](CC3=CC=CC=C3)NC([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@H](C)NC([C@H](C)NC(C6=CC=CC=C6)=O)=O)=O)=O)=O)CCC2)=O)CCC1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 904.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Arkinstall S, Edgerton M, Payton M, Maundrell K. Co-expression of the neurokinin NK2 receptor and G-protein components in the fission yeast Schizosaccharomyces pombe. FEBS Lett. 1995 Nov 20;375(3):183-7. PubMed PMID: 7498495.

8: Maggi CA, Giuliani S. Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine. Br J Pharmacol. 1996 Jul;118(5):1262-8. PubMed PMID: 8818352; PubMed Central PMCID: PMC1909582.

9: Maggi CA, Zagorodnyuk V, Giuliani S. Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon. Regul Pept. 1994 Oct 21;53(3):259-74. PubMed PMID: 7531357.

10: Bradshaw CG, Ceszkowski K, Turcatti G, Beresford IJ, Chollet A. Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor. J Med Chem. 1994 Jun 24;37(13):1991-5. PubMed PMID: 8027981.

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