BePI

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563242

CAS#: 133712-11-5

Description: BePI is a specific intercalator of both double and triple-helical DNA.

Chemical Structure

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BePI
CAS# 133712-11-5
Instruction

Theoretical Analysis

MedKoo Cat#: 563242
Name: BePI
CAS#: 133712-11-5
Chemical Formula: C20H22N4O
Exact Mass: 334.18
Molecular Weight: 334.420
Elemental Analysis: C, 71.83; H, 6.63; N, 16.75; O, 4.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BePI; Be-PI; Be PI; NSC-664711; NSC 664711; NSC664711;

IUPAC/Chemical Name: 3-Methoxy-7H-8-methyl-11-[(3'-amino)propylamino]-benzo[e]pyrido[4,3-b]indole

InChi Key: ZRXYNJUDISKEAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H22N4O/c1-12-11-23-20(22-9-3-8-21)18-17-15-6-5-14(25-2)10-13(15)4-7-16(17)24-19(12)18/h4-7,10-11,24H,3,8-9,21H2,1-2H3,(H,22,23)

SMILES Code: NCCCNC1=NC=C(C)C(N2)=C1C3=C2C=CC4=CC(OC)=CC=C34

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 334.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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8: Keppler MD, Neidle S, Fox KR. Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands. Nucleic Acids Res. 2001 May 1;29(9):1935-42. PubMed PMID: 11328877; PubMed Central PMCID: PMC37244.

9: Walter A, Schütz H, Simon H, Birch-Hirschfeld E. Evidence for a DNA triplex in a recombination-like motif: I. Recognition of Watson-Crick base pairs by natural bases in a high-stability triplex. J Mol Recognit. 2001 Mar-Apr;14(2):122-39. PubMed PMID: 11301482.

10: Marchand C, Nguyen CH, Ward B, Sun JS, Bisagni E, Garestier T, Hélène C. A new family of sequence-specific DNA-cleaving agents directed by triple-helical structures: benzopyridoindole-EDTA conjugates. Chemistry. 2000 May 2;6(9):1559-63. PubMed PMID: 10839173.

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17: Marchand C, Bailly C, Nguyen CH, Bisagni E, Garestier T, Hélène C, Waring MJ. Stabilization of triple helical DNA by a benzopyridoquinoxaline intercalator. Biochemistry. 1996 Apr 16;35(15):5022-32. PubMed PMID: 8664295.

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