Laminin B1 (1363-1383)

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597590

CAS#: 112761-58-7

Description: Laminin B1 (1363-1383) is the Residue 1363-1383 of laminin B1 chain, KLQSLDLSAAAQMTCGTPPGA.

Chemical Structure

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Laminin B1 (1363-1383)
CAS# 112761-58-7
Instruction

Theoretical Analysis

MedKoo Cat#: 597590
Name: Laminin B1 (1363-1383)
CAS#: 112761-58-7
Chemical Formula: C72H122N20O25S
Exact Mass: 1,698.86
Molecular Weight: 1,699.940
Elemental Analysis: C, 50.87; H, 7.23; N, 16.48; O, 23.53; S, 1.89

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Laminin B1 (1363-1383); Yosh-4; Yosh 4; Yosh4;

IUPAC/Chemical Name: (2R,3S,9R,12S,15S,18S,21S,24S,27S)-3-((S)-2-((S)-2-((2-(((S)-1-carboxyethyl)amino)-2-oxoethyl)carbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carbonyl)-27-((2S,5S,8S,11S,14S)-14,18-diamino-8-(3-amino-3-oxopropyl)-5-(hydroxymethyl)-2,11-diisobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctadecanamido)-2-hydroxy-21-(hydroxymethyl)-24-isobutyl-9-(mercaptomethyl)-12,15,18-trimethyl-5,8,11,14,17,20,23,26-octaoxo-4,7,10,13,16,19,22,25-octaazanonacosan-29-oic acid

InChi Key: NOISUCZESHIQOS-WXJFWQIXSA-N

InChi Code: InChI=1S/C72H122N20O25S/c1-33(2)24-43(83-60(104)41(74)16-12-13-21-73)63(107)82-42(19-20-52(75)96)62(106)87-48(31-94)68(112)85-44(25-34(3)4)64(108)86-46(27-55(99)100)66(110)84-45(26-35(5)6)65(109)88-47(30-93)67(111)81-37(8)58(102)79-36(7)57(101)80-38(9)59(103)89-49(32-118)61(105)76-29-54(98)90-56(40(11)95)71(115)92-23-15-18-51(92)70(114)91-22-14-17-50(91)69(113)77-28-53(97)78-39(10)72(116)117/h33-51,56,93-95,118H,12-32,73-74H2,1-11H3,(H2,75,96)(H,76,105)(H,77,113)(H,78,97)(H,79,102)(H,80,101)(H,81,111)(H,82,107)(H,83,104)(H,84,110)(H,85,112)(H,86,108)(H,87,106)(H,88,109)(H,89,103)(H,90,98)(H,99,100)(H,116,117)/t36-,37-,38-,39-,40+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,56-/m0/s1

SMILES Code: C[C@@H](C(O)=O)NC(CNC([C@H]1N(C([C@H]2N(C([C@H]([C@H](O)C)NC(CNC([C@H](CS)NC([C@H](C)NC([C@H](C)NC([C@H](C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC2)=O)CCC1)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,699.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Siironen J, Vuorio E, Sandberg M, Röyttä M. Expression of type I and III collagen and laminin beta1 after rat sciatic nerve crush injury. J Peripher Nerv Syst. 1996;1(3):209-21. PubMed PMID: 10970111.

2: Nakai M, Mundy GR, Williams PJ, Boyce B, Yoneda T. A synthetic antagonist to laminin inhibits the formation of osteolytic metastases by human melanoma cells in nude mice. Cancer Res. 1992 Oct 1;52(19):5395-9. PubMed PMID: 1394144.

3: Shao FJ, Cheng J, Ma YJ, Yang Q, Ji D, Wang L. [Study on the effects of human augmenter of liver regeneration on laminin B1 chain gene promoter]. Zhonghua Gan Zang Bing Za Zhi. 2006 Jan;14(1):70-1. Chinese. PubMed PMID: 16420775.

4: Dong S, Landfair J, Balasubramani M, Bier ME, Cole G, Halfter W. Expression of basal lamina protein mRNAs in the early embryonic chick eye. J Comp Neurol. 2002 Jun 3;447(3):261-73. PubMed PMID: 11984820.