Enkephalin-met, lys(6)-

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597550

CAS#: 75909-25-0

Description: Enkephalin-met, lys(6)- is an opioid hexapeptide found in adrenal medulla & brain.

Chemical Structure

img
Enkephalin-met, lys(6)-
CAS# 75909-25-0
Instruction

Theoretical Analysis

MedKoo Cat#: 597550
Name: Enkephalin-met, lys(6)-
CAS#: 75909-25-0
Chemical Formula: C33H47N7O8S
Exact Mass: 701.32
Molecular Weight: 701.840
Elemental Analysis: C, 56.47; H, 6.75; N, 13.97; O, 18.24; S, 4.57

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Enkephalin-met, lys(6)-; Met-enk-L; 6-Lys-met-enkephalin;

IUPAC/Chemical Name: L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-lysine

InChi Key: CFOVZGFKVVQYMH-FWEHEUNISA-N

InChi Code: InChI=1S/C33H47N7O8S/c1-49-16-14-25(31(45)40-26(33(47)48)9-5-6-15-34)39-32(46)27(18-21-7-3-2-4-8-21)38-29(43)20-36-28(42)19-37-30(44)24(35)17-22-10-12-23(41)13-11-22/h2-4,7-8,10-13,24-27,41H,5-6,9,14-20,34-35H2,1H3,(H,36,42)(H,37,44)(H,38,43)(H,39,46)(H,40,45)(H,47,48)/t24-,25-,26-,27-/m0/s1

SMILES Code: NCCCC[C@@H](C(O)=O)NC([C@H](CCSC)NC([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 701.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Rossier J, Dean DM, Livett BG, Udenfriend S. Enkephalin congeners and precursors are synthesized and released by primary cultures of adrenal chromaffin cells. Life Sci. 1981 Feb 16;28(7):781-9. PubMed PMID: 7231054.

2: Bergström L, Lagercrantz H, Terenius L. Post-mortem analyses of neuropeptides in brains from sudden infant death victims. Brain Res. 1984 Dec 10;323(2):279-85. PubMed PMID: 6084539.

3: Nicholson LM, Patel HB, Kristjansson F, Crowley SC Jr, Dave K, Stobaugh JF, Riley CM. Multidimensional liquid chromatography of opioid peptides: fluorogenic labelling, retention prediction and separation optimization. J Pharm Biomed Anal. 1990;8(8-12):805-16. PubMed PMID: 2100627.

4: Stern AS, Lewis RV, Kimura S, Rossier J, Stein S, Udenfriend S. Opioid hexapeptides and heptapeptides in adrenal medulla and brain possible implications on the biosynthesis of enkephalins. Arch Biochem Biophys. 1980 Dec;205(2):606-13. PubMed PMID: 6258484.

5: Williams RG, Dockray GJ. Differential distribution in rat basal ganglia of Met-enkephalin- and Met-enkephalin Arg6 Phe7-like peptides revealed by immunohistochemistry. Brain Res. 1982 May 20;240(1):167-70. PubMed PMID: 7046877.