Monopotassium glutamate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597269

CAS#: 19473-49-5

Description: Monopotassium glutamate is a salts and ester of glutamic acid.

Chemical Structure

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Monopotassium glutamate
CAS# 19473-49-5
Instruction

Theoretical Analysis

MedKoo Cat#: 597269
Name: Monopotassium glutamate
CAS#: 19473-49-5
Chemical Formula: C5H8KNO4
Exact Mass: 0.00
Molecular Weight: 185.220
Elemental Analysis: C, 32.42; H, 4.35; K, 21.11; N, 7.56; O, 34.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Monopotassium glutamate; Potassium glutamate;

IUPAC/Chemical Name: potassium (S)-2-amino-4-carboxybutanoate

InChi Key: HQEROMHPIOLGCB-DFWYDOINSA-M

InChi Code: InChI=1S/C5H9NO4.K/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1

SMILES Code: N[C@@H](CCC(O)=O)C([O-])=O.[K+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 185.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ruggiero MT, Sibik J, Erba A, Zeitler JA, Korter TM. Quantification of cation-anion interactions in crystalline monopotassium and monosodium glutamate salts. Phys Chem Chem Phys. 2017 Nov 1;19(42):28647-28652. doi: 10.1039/c7cp05544g. PubMed PMID: 29043315.

2: Green BG, Alvarado C, Andrew K, Nachtigal D. The Effect of Temperature on Umami Taste. Chem Senses. 2016 Jul;41(6):537-45. doi: 10.1093/chemse/bjw058. Epub 2016 Apr 20. PubMed PMID: 27102813; PubMed Central PMCID: PMC4918727.

3: Tokita K, Boughter JD Jr. Topographic organizations of taste-responsive neurons in the parabrachial nucleus of C57BL/6J mice: An electrophysiological mapping study. Neuroscience. 2016 Mar 1;316:151-66. doi: 10.1016/j.neuroscience.2015.12.030. Epub 2015 Dec 19. PubMed PMID: 26708748; PubMed Central PMCID: PMC4724509.

4: Pal Choudhuri S, Delay RJ, Delay ER. Metabotropic glutamate receptors are involved in the detection of IMP and L-amino acids by mouse taste sensory cells. Neuroscience. 2016 Mar 1;316:94-108. doi: 10.1016/j.neuroscience.2015.12.008. Epub 2015 Dec 14. PubMed PMID: 26701297.

5: Yoshida Y, Kawabata Y, Kawabata F, Nishimura S, Tabata S. Expressions of multiple umami taste receptors in oral and gastrointestinal tissues, and umami taste synergism in chickens. Biochem Biophys Res Commun. 2015 Oct 23;466(3):346-9. doi: 10.1016/j.bbrc.2015.09.025. Epub 2015 Sep 7. PubMed PMID: 26361143.

6: Pal Choudhuri S, Delay RJ, Delay ER. L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors. PLoS One. 2015 Jun 25;10(6):e0130088. doi: 10.1371/journal.pone.0130088. eCollection 2015. PubMed PMID: 26110622; PubMed Central PMCID: PMC4482487.

7: Saites LN, Goldsmith Z, Densky J, Guedes VA, Boughter JD Jr. Mice perceive synergistic umami mixtures as tasting sweet. Chem Senses. 2015 Jun;40(5):295-303. doi: 10.1093/chemse/bjv010. Epub 2015 Mar 28. PubMed PMID: 25820205; PubMed Central PMCID: PMC4498132.

8: Kudo K, Kawabata F, Nomura T, Aridome A, Nishimura S, Tabata S. Isolation of chicken taste buds for real-time Ca2+ imaging. Anim Sci J. 2014 Oct;85(10):904-9. doi: 10.1111/asj.12222. Epub 2014 May 19. PubMed PMID: 24840958.

9: Zhu X, He L, McCluskey LP. Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice. Neuroscience. 2014 Jan 31;258:47-61. doi: 10.1016/j.neuroscience.2013.10.072. Epub 2013 Nov 9. PubMed PMID: 24215981; PubMed Central PMCID: PMC4020010.

10: Boucher Y, Felizardo R, Klein AH, Carstens MI, Carstens E. Gustatory modulation of the responses of trigeminal subnucleus caudalis neurons to noxious stimulation of the tongue in rats. Eur J Neurosci. 2013 Sep;38(6):2812-22. doi: 10.1111/ejn.12282. Epub 2013 Jun 27. PubMed PMID: 23802589; PubMed Central PMCID: PMC4591004.

11: Perez IO, Villavicencio M, Simon SA, Gutierrez R. Speed and accuracy of taste identification and palatability: impact of learning, reward expectancy, and consummatory licking. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 1;305(3):R252-70. doi: 10.1152/ajpregu.00492.2012. Epub 2013 May 15. PubMed PMID: 23678029.

12: Pajęcka K, Nielsen CW, Hauge A, Zaganas I, Bak LK, Schousboe A, Plaitakis A, Waagepetersen HS. Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization. Neurochem Res. 2014;39(3):487-99. doi: 10.1007/s11064-013-1042-z. Epub 2013 Apr 26. PubMed PMID: 23619558.

13: Türkoğlu Ş. Evaluation of genotoxic effects of five flavour enhancers (glutamates) on the root meristem cells of Allium cepa. Toxicol Ind Health. 2015 Sep;31(9):792-801. doi: 10.1177/0748233713475509. Epub 2013 Feb 1. PubMed PMID: 23377115.

14: Tokita K, Boughter JD Jr. Sweet-bitter and umami-bitter taste interactions in single parabrachial neurons in C57BL/6J mice. J Neurophysiol. 2012 Oct;108(8):2179-90. doi: 10.1152/jn.00465.2012. Epub 2012 Jul 25. PubMed PMID: 22832571; PubMed Central PMCID: PMC3545017.

15: Yasumatsu K, Ogiwara Y, Takai S, Yoshida R, Iwatsuki K, Torii K, Margolskee RF, Ninomiya Y. Umami taste in mice uses multiple receptors and transduction pathways. J Physiol. 2012 Mar 1;590(5):1155-70. doi: 10.1113/jphysiol.2011.211920. Epub 2011 Dec 19. PubMed PMID: 22183726; PubMed Central PMCID: PMC3381822.

16: Tokita K, Yamamoto T, Boughter JD Jr. Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice. J Neurophysiol. 2012 Mar;107(6):1545-55. doi: 10.1152/jn.00799.2011. Epub 2011 Dec 14. PubMed PMID: 22170968; PubMed Central PMCID: PMC3311675.

17: Yamamoto T, Watanabe U, Fujimoto M, Sako N. Taste preference and nerve response to 5'-inosine monophosphate are enhanced by glutathione in mice. Chem Senses. 2009 Nov;34(9):809-18. doi: 10.1093/chemse/bjp070. Epub 2009 Oct 1. PubMed PMID: 19797341.

18: Chen QY, Alarcon S, Tharp A, Ahmed OM, Estrella NL, Greene TA, Rucker J, Breslin PA. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. Am J Clin Nutr. 2009 Sep;90(3):770S-779S. doi: 10.3945/ajcn.2009.27462N. Epub 2009 Jul 8. PubMed PMID: 19587085; PubMed Central PMCID: PMC3136006.

19: Kitagawa J, Takahashi Y, Matsumoto S, Shingai T. Response properties of the pharyngeal branch of the glossopharyngeal nerve for umami taste in mice and rats. Neurosci Lett. 2007 Apr 24;417(1):42-5. Epub 2007 Feb 11. PubMed PMID: 17321681.

20: He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomiya Y, Margolskee RF, Damak S. Umami taste responses are mediated by alpha-transducin and alpha-gustducin. J Neurosci. 2004 Sep 1;24(35):7674-80. PubMed PMID: 15342734.